Method for terminating methadone maintenance through extinction of the opiate-taking responses

• US 5,587,381 A
• Filed: 03/27/1995
• Issued: 12/24/1996
• Est. Priority Date: 03/27/1995
• Status: Expired due to Term

• Current Assignee: Lightlake Therapeutics Inc.
• Original Assignee: John D. Sinclair
• Inventors: Sinclair, John D.
• Primary Examiner(s): Travers, Russell
• Assistant Examiner(s): Jarvis, William R. A.
• Application Number:
  US08/410,529
• Time in Patent Office: 638 Days
• Field of Search: 514/282, 514/295, 514/279, 514/289, 514/648
• US Class Current: 514/282
• CPC Class Codes: A61K 31/439 the ring forming part of a bridged ring system, e.g. quinuclidine 8-azabicyclo [3.2.1] octanes A61K31/46
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine

Abstract

A method is provided for effectively terminating methadone maintenance therapy and the addiction to other legally-available opiates by selectively extinguishing the opiate-taking responses. Selective extinction is produced having sessions in which detoxified addicts make opiate-taking responses while an opiate antagonist blocks the positive reinforcement, interspersed by periods when the antagonist is absent and all responses except opiate-taking can be emitted. A similar method but with instructions not to take the opiate can subsequently be used to protect against resumption of illegal opiate use, or separately with patients addicted to illegal opiates producing reinforcement through the opioidergic system.

Claims

1. A method for terminating methadone maintenance therapy and addiction to other legally-available opiates by selective extinction of the opiate-taking response, comprising the steps of:

withholding all opiates from a subject suffering from addiction to a legally-available opiate for a sufficient time to prevent an opiate antagonist when administered to the subject from causing precipitous withdrawal; and

thereafter administering to the subject an opiate antagonist selected from the group consisting of nalmefene, naltrexone, naloxone, cyclazocine, etazocine, levallorphan, metazocine, nalorphine, and salts thereof in a daily dosage sufficient to block the effects of opiate agonists;

while the amount of the antagonist in the subject'"'"'s body is sufficient to block opiate effects, having the subject self-administer the legally-available opiate agonist to which he or she is addicted;

withholding the opiate antagonist from the subject;

when the amount of antagonist is no longer sufficient to block opiate effects, not allowing the subject to self-administer opiates; and

continuing the above steps of administration of the opiate antagonist and the subject'"'"'s taking of the opiate and the withholding of the antagonist for a period when the subject cannot take opiates until the opiate-taking behavior is extinguished.

4. The method in accordance with claim 1, 2 or 3 wherein the opiate antagonist is nalmefene.

5. The method in accordance with claim 4 wherein nalmefene is given in doses from 0.1 to 300 mg daily.

6. The method in accordance with claim 1, 2 or 3 wherein the opiate antagonist is naltrexone.

7. The method in accordance with claim 6 wherein naltrexone is given in doses from 10 to 300 mg daily.

8. The method in accordance with claim 1, 2 or 3 wherein the opiate antagonist is naloxone.

9. The method in accordance with claim 8 wherein naloxone is given in doses from 0.2 to 30 mg daily.

2. A method for treating opiate addiction through selective extinction, comprising the steps of:

repeatedly administering to a subject, suffering from opiate addiction but not physiologically dependent upon opiates, an opiate antagonist selected from the group consisting of nalmefene, naltrexone, naloxone, cyclazocine, etazocine, levallorphan, metazocine, nalorphine, and salts thereof in a daily dosage sufficient to block the effects of opiate agonists;

while the amount of the antagonist in the subject'"'"'s body is sufficient to block opiate effects, having the subject make the responses the subject has usually made in the past in preparation for self-administration of an opiate but with instructions not to self-administer an opiate;

withholding the antagonist from the subject;

when the amount of antagonist is no longer sufficient to block opiate effects, not allowing the subject to make the preparatory responses but continuing instructions not to self-administer an opiate; and

continuing the above steps of administration of the opiate antagonist and making the preparatory responses and the period free of the antagonist when preparatory responses and opiate-taking responses cannot be made until these responses are extinguished.

3. A method for terminating methadone maintenance therapy and addiction to other legally-available opiates and for treating addiction to illegal opiates in the same subject by selective extinction of the responses of taking the legally-available opiate and selective extinction of the responses made in preparation for taking the illegal opiate, comprising the steps of:

withholding all opiates from a subject suffering from addiction to a legally-available opiate for a sufficient time to prevent an opiate antagonist when administered to the subject from causing precipitous withdrawal; and

thereafter administering to the subject an opiate antagonist selected from the group consisting of nalmefene, naltrexone, naloxone, cyclazocine, diprenorphine, etazocine, levalorphan, metazocine, nalorphine, and salts thereof in a daily dosage sufficient to block the effects of opiate agonists;

while the amount of the antagonist in the subject'"'"'s body is sufficient to block opiate effects, having the subject self-administer the legally-available opiate agonist to which he or she is addicted;

withholding the opiate antagonist from the subject;

when the amount of antagonist is no longer sufficient to block opiate effects, not allowing the subject to self-administer opiates; and

continuing the above steps of administration of the opiate antagonist and the subject'"'"'s taking of the legally-available opiate agonist and the withholding of the antagonist for a period when the subject cannot take opiates until the opiate-taking behavior is extinguished; and

thereafter

repeatedly administering to the subject said opiate antagonist;

while the amount of antagonist in the subject'"'"'s body is sufficient to block opiate effects, having the subject make the responses the subject had usually made in the past in preparation for self-administration of an illegal opiate but with instructions not to self-administer an opiate;

withholding the antagonist from the subject;

when the amount of antagonist is no longer sufficient to block opiate effects, not allowing the subject to make the preparatory responses but continuing instructions not to self-administer an opiate; and

continuing the above steps of administration of the opiate antagonist and making the preparatory responses and the period free of the antagonist when preparatory responses and opiate-taking responses cannot be made until these responses are extinguished.