Blood flow determination

• US 5,588,437 A
• Filed: 02/16/1994
• Issued: 12/31/1996
• Est. Priority Date: 03/29/1989
• Status: Expired due to Term

• Current Assignee: British Technology Group Ltd.
• Original Assignee: British Technology Group Ltd.
• Inventors: Essex, Timothy J. H., Byrne, Phillip O.
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): ZUTTARELLI, ANTHONY
• Application Number:
  US08/197,442
• Time in Patent Office: 1,049 Days
• Field of Search: 128/633, 128/653.1, 128/664-667, 128/691, 128/693, 356/39-42, 356/27, 356/28
• US Class Current: 600/504
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light

Abstract

A method of determination of blood flow including projecting a beam (B) of laser generated light (L) to move (SM) over a surface (T) beneath which blood flow in a vessel or vascular bed is to be determined, collecting (RD)light returning scattered from the beam by the surface and by blood flowing beneath, measuring a spectrum of frequencies in said collected light, determining (DA),(F) from differences in said frequencies blood flow (VS) in a vessel or vascular bed beneath said surface. A reference for the detected frequencies is provided by light returned from the surface. A map of blood flow in a false-colour flow scale can be displayed(DU).

Claims

1. A method of determination of blood flow to produce a map of said blood flow, said method comprising the steps of:

scanning a rod of laser light in two directions over an area of a surface beneath which area of the surface blood flow in a vessel or vascular bed is to be determined,

collecting light returning from the rod of light scattered by the surface and by blood flowing beneath the surface,

measuring a spectrum of frequencies in said collected light,

determining, from differences in said frequencies in said spectrum, blood flow in a vessel or vascular bed beneath said surface, and

producing from said determined blood flow the map of blood flow for a given area of said surface.

2. A method according to claim 1 further comprising the step of:

presenting said determined blood flow as an image of the surface colored or shaded in accordance with a scale of blood flow.

3. A method according to claim 1 further comprising the step of:

providing a reference for the detected frequencies of light returned from the surface for the determination of blood flow beneath the surface.

4. A method of determination of blood flow further comprising the step of:

generating and projecting a rod of laser light,

causing said rod of light to scan in two directions over a surface beneath which surface blood flow in a vessel or vascular bed is to be determined,

generating rod-motion information related to said moving light rod,

collecting light returning from the rod and scattered by the surface and by blood flowing beneath,

detecting scatter-related frequencies in said collected light, and

determining, from at least said rod-motion information and said detected frequencies, blood flow in a vessel or vascular bed beneath said surface.

5. A method according to claim 4 further comprising the step of:

projecting said rod over a space of two meters to a target surface one meter by half a meter in area.

6. A method according to claim 4 further comprising the step of:

providing from the detected frequencies of light returned from the surface a reference for the determination of blood flow beneath the surface against movement of said surface.

7. A method according to claim 4 further comprising the step of:

causing said rod to move in two substantially mutually perpendicular directions over the surface, and

producing from said determined blood flow a map of blood flow for a given area of said surface colored or shaded in accordance with a scale of blood flow.

8. A method according to claim 4 further comprising the step of further comprising the step of:

causing said rod to move over the surface in a raster scan.

9. A method according to claim 4 further comprising the step of:

providing one raster direction scan motion by a smooth linkage drive, and

providing another raster direction scan motion by a stepper motion.

10. A method according to claim 4 further comprising the step of:

reflecting the rod in a movable mirror,

driving the mirror and smoothly to-and-fro in one direction of the raster and driving the mirror step-wise in another direction between said smooth drives.

11. Apparatus to determine blood flow comprising:

a low-noise laser,

means for directing a rod of light from said laser to a target,

means for scanning the directed rod over said target in two dimensions, thereby causing said target to return the light,

means for collecting light from the rod returned from said target,

means for detecting frequencies in said collected light, and

means responsive to the action of the means for scanning said rod and to said detected collected light frequencies for determining localized target velocity information related to the scan over the target and for providing said information as a scan-based signal.

12. Apparatus according to claim 11 further comprising means for presenting said scan-based information as an image of localized velocity information for the target.

13. Apparatus according to claim 11 wherein the velocity information is information about blood flow below the surface of the target.

14. Apparatus according to claim 11 wherein the blood flow velocity information is presented as a false-color image of the blood flow in the target.

15. Apparatus according to claim 11 wherein the means for detecting returned light is an array of detectors.

16. Apparatus according to claim 15 wherein the laser rod is arranged to pass through an aperture in the array and then along a path also used for the returned light.

17. Apparatus according to claim 11 wherein the returned light frequencies include those representing overall movement of the target which provide a reference for determination of localized velocity information.

18. Apparatus according to claim 11 wherein the means for scanning the directed rod include means to drive a mirror directing the beam in a steady swinging motion and in a stepwise tilting motion.

19. Apparatus according to claim 15 wherein the detectors are four in number arranged in pairs, the output of detectors in a pair are added to give two combined outputs which are then differenced to provide a signal representing frequencies in said collected light.