Silicon-based sleeve devices for chemical reactions
First Claim
1. In a microfabricated chemical reactor having a reaction chamber, the improvement comprising:
- a sleeve reaction chamber,said sleeve reaction chamber having a slot therein,said slot being constructed to enable insertion of an insert or liner therein, andheating means for said sleeve reaction chamber.
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Accused Products
Abstract
A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.
551 Citations
22 Claims
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1. In a microfabricated chemical reactor having a reaction chamber, the improvement comprising:
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a sleeve reaction chamber, said sleeve reaction chamber having a slot therein, said slot being constructed to enable insertion of an insert or liner therein, and heating means for said sleeve reaction chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification