Surface-modifying endgroups for biomedical polymers
First Claim
1. A surface active endgroup-containing polymer that comprises a linear base polymer having covalently bonded surface active endgroups of a nature and present in an amount such that said polymer has a surface or interfacial tension that differs by at least 1 dyne/cm from the surface or interfacial tension of an otherwise identical polymer having diethylamino endgroups.
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Abstract
The present invention relates to novel polymeric compositions of matter and their use. Said polymeric compositions of matter are surface active endgroup-containing polymers that comprise a linear base polymer having covalently bonded surface active endgroups of a nature and present in an amount such that said polymers have a surface or interfacial tension that differs by at least 1 dyne/cm from the surface or interfacial tension of an otherwise identical polymer that does not contain said covalently bonded surface active endgroups. The novel linear polymers according to the present invention are particularly suitable for use in the manufacture of medical devices, and especially of medical devices intended to be used in contact with bodily fluids such as blood. Examples of such medical devices include catheters and artificial hearts.
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51 Claims
- 1. A surface active endgroup-containing polymer that comprises a linear base polymer having covalently bonded surface active endgroups of a nature and present in an amount such that said polymer has a surface or interfacial tension that differs by at least 1 dyne/cm from the surface or interfacial tension of an otherwise identical polymer having diethylamino endgroups.
- 35. A surface active endgroup-containing polymer that comprises a linear base polymer having covalently bonded surface active endgroups of a nature and present in an amount such that said polymer has a contact angle hysteresis of the surface that is changed by at least 5% from the contact angle hysteresis of the surface of an otherwise identical polymer that does not contain said covalently bonded surface active endgroups.
- 37. A segmented block copolymer comprising from about 5 to 45 weight % of at least one hard segment, from about 95 to 55 weight % of at least one soft segment, and from about 0.1 to 15 weight % of at least one surface active endgroup.
- 39. A polymeric composition of matter having the formula
- space="preserve" listing-type="equation">A.sub.p A'"'"'.sub.1-p [BCD].sub.n Z.sub.q Z'"'"'.sub.1-q
wherein p and q may be the same or different and each is a number from 0 through 1, n is a number from 5 through 105, A is a surface active endgroup, A'"'"' is a surface active endgroup different from A, Z is a surface active endgroup that may be the same as one of or different from both of A and A'"'"', and z" is a surface active endgroup that is different from Z but may be the same as one of or different from both of A and A'"'"', B is a polymer block, C is a polymer block which may be the same as or different from B, and D is a polymer block which may be the same as one of or different from both of B and C. - View Dependent Claims (40, 41, 42, 43)
Specification