Integrin alpha subunit cytoplasmic domain polypeptides and methods

• US 5,589,570 A
• Filed: 05/10/1994
• Issued: 12/31/1996
• Est. Priority Date: 05/03/1991
• Status: Expired due to Fees

• Current Assignee: The Scripps Research Institute
• Original Assignee: The Scripps Research Institute
• Inventors: Quaranta, Vito, Tamura, Richard N.
• Primary Examiner(s): Draper, Garnette D.
• Assistant Examiner(s): SPECTOR, LORRAINE
• Application Number:
  US08/241,387
• Time in Patent Office: 966 Days
• Field of Search: 530/324-326, 530/350, 530/388.2, 514/13, 514/14, 435/69.3
• US Class Current: 530/350
• CPC Class Codes: C07K 14/70546 Integrin superfamily
• CPC Class Codes: C07K 16/2839 against the integrin superfamily
• CPC Class Codes: C07K 2317/34 Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Abstract

Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of the cytoplasmic domain of the integrin α_6B or α_3B subunit in a body sample are disclosed.

Claims

1. An isolated polypeptide of about 24 to about 1091 amino acid residues in length having a sequence that corresponds in sequence to the α

_6B subunit sequence shown in SEQ ID NO 3 and the includes the α

_6B cytoplasmic domain from residues 1068 to 1091 shown in SEQ ID NO 3.

2. The isolated polypeptide of claim 1 wherein said polypeptide consists of an amino acid residue sequence selected from the group consisting of sequences shown in SEQ ID NO 3 from residue 1068 to residue 1091, from residue 1045 to residue 1091, and from residue 1 to residue 1091.