Apparatus and method for measuring an induced perturbation to determine blood pressure

• US 5,590,649 A
• Filed: 04/15/1994
• Issued: 01/07/1997
• Est. Priority Date: 04/15/1994
• Status: Expired due to Term

• Current Assignee: Canon Kabushiki Kaisha (Canon Inc.), Masimo Corporation
• Original Assignee: Vital Insite, Inc.
• Inventors: Caro, Richard G., Sher, Mark H.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Nasser, Robert L.
• Application Number:
  US08/228,213
• Time in Patent Office: 998 Days
• Field of Search: 128/632, 128/633, 128/630, 128/664-668, 128/672-694, 128/696, 128/713, 128/716, 128/719, 128/721, 128/722, 128/736, 128/748
• US Class Current: 600/300
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/02133 by using induced vibration of the blood vessel
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers

Abstract

A monitor for continuously determining a patient'"'"'s physiological parameter includes a means for obtaining a periodic calibration measurement of the patient'"'"'s physiological parameter. An exciter, positioned over an artery of the patient induces an exciter waveform into the patient'"'"'s arterial blood. A noninvasive sensor, positioned over the artery, senses a hemoparameter and provides a noninvasive sensor signal output representative of the hemoparameter. A processor receives the calibration measurement and noninvasive sensor signal output. The processor determines a DC offset based on the calibration measurement and processes the noninvasive sensor signal to continuously determine the patient'"'"'s physiological parameter. A method includes steps for performing the present invention. In the preferred embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters such as vascular wall compliance, strength of ventricular contractions, vascular resistance, fluid volume, cardiac output, myocardial contractility and other related parameters.

Claims

1. A monitor for determining a patient'"'"'s physiological parameter, comprising:

a calibration device configured to provide a calibration signal representative of the patient'"'"'s physiological parameter;

an exciter, positioned over a blood vessel of the patient, for inducing a transmitted exciter waveform into the patient;

a noninvasive sensor, positioned over said blood vessel, said noninvasive sensor configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of said hemoparameter containing a component of a received exciter waveform;

a processor configured to determine a relationship between a property of said received exciter waveform and a property of the physiological parameter; and

wherein said processor is connected to receive said calibration signal and said noninvasive sensor signal, said processor configured to determine said physiological parameter based at least in part on said calibration signal, said noninvasive sensor signal, and said relationship.

2. The monitor of claim 1, wherein:

said processor includes a filter configured to separate from said noninvasive sensor signal a component of one of the group consisting of said physiological parameter waveform, said received exciter waveform, signal exciter waveform and a noise waveform.

3. The monitor of claim 1, wherein:

said processor includes a filter configured to separate from said noninvasive sensor signal a component having a time-varying phase.

4. The monitor of claim 1, wherein:

said processor includes a filter configured to determine an arc representing time varying positions of said received exciter waveform, to determine a center point of said arc and to determine a noise vector from an origin to said center point; and

said processor is configured to determine an arc vector from said center point to said time varying positions, where said arc vector has an arc vector angle that moves from a first angle to a second angle over time; and

wherein said processor is configured to process said arc vector angle to determine the physiological parameter.

5. The monitor of claim 1, wherein:

said exciter is further configured to induce a second transmitted exciter waveform into the patient; and

said processor includes a filter configured to separate from said noninvasive sensor signal a component of one of the group consisting of said physiological parameter waveform, said received exciter waveform, a second received exciter waveform, a signal exciter waveform, second signal exciter waveform and a noise waveform.

6. The monitor of one of claims 1, 2, 3 or 4, wherein:

said processor is further configured to determine a relationship between a component of said received exciter waveform and an amplitude and DC offset of the physiological parameter.

7. The monitor of one of claims 1, 2, 3 or 4, wherein:

said processor is further configured to determine a relationship between an amplitude and phase of a component of said received exciter waveform and an amplitude and DC offset of the physiological parameter.

8. The monitor of one of claims 1, 2, 3, 4 or 5, wherein:

said processor is responsive to said noninvasive sensor signal, and further configured to determine the validity of said calibration signal and to initiate a calibration when said calibration signal is not valid.

9. The monitor of one of claims 1, 2, 3, 4 or 5, wherein:

said processor is further configured to scale said physiological parameter waveform based on the relationship between a property of said received exciter waveform and a property of the physiological parameter and to generate a scaled physiological parameter waveform signal.

10. A processor for determining a patient'"'"'s physiological parameter with an apparatus having a calibration device configured to provide a calibration signal representative of the patient'"'"'s physiological parameter, an exciter positioned over a blood vessel of the patient for inducing a transmitted exciter waveform into the patient, and a noninvasive sensor positioned over said blood vessel, said noninvasive sensor configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of said hemoparameter, said processor comprising:

a first input configured to receive said calibration signal;

a second input configured to receive said noninvasive sensor signal;

a filter configured to separate from said noninvasive sensor signal a component representing a received exciter waveform;

a relationship routine configured to determine a relationship between a property of said received exciter waveform and a property of said physiological parameter; and

a determination routine configured to determine said physiological parameter based at least in part on said calibration signal, said noninvasive sensor signal, and said relationship.

11. The processor of claim 10, wherein:

said filter is configured to separate from said noninvasive sensor signal a component having a time-varying phase.

12. The processor of claim 10, wherein:

said filter is configured to determine an arc representing time varying positions of said received exciter waveform, to determine a center point of said arc and to determine a noise vector from an origin to said center point; and

said filter is configured to determine an arc vector from said center point to said time varying positions, where said arc vector has an arc vector angle that moves from a first angle to a second angle over time; and

wherein said determination routine is configured to process said arc vector angle to determine the physiological parameter.

13. The processor of one of claims 10, 11 or 12, wherein:

said determination routine is further configured to compare a phase relationship between said transmitted exciter waveform and a component of said noninvasive sensor signal to determine the physiological parameter.

14. The processor of one of claims 10, 11 or 12, wherein:

said filter is further configured to separate from said noninvasive sensor signal a component representing a second received exciter waveform.

15. The processor of one of claims 10, 11 or 12, wherein:

said determination routine is further configured to compare a phase relationship between said transmitted exciter waveform and a component of said noninvasive sensor signal, and to compare a phase relationship between a second transmitted exciter waveform and a component of said noninvasive sensor signal to determine the physiological parameter.

16. A method of determining a patient'"'"'s physiological parameter, comprising the steps of:

providing a calibration signal representative of the patient'"'"'s physiological parameter and storing the calibration signal;

inducing a transmitted exciter waveform into the patient;

noninvasively sensing a hemoparameter, and generating a noninvasive sensor signal representative of said hemoparameter and containing a component of a received exciter waveform;

determining a relationship between a property of said received exciter waveform and a property of the physiological parameter; and

determining said physiological parameter based at least in part on said calibration signal, said non-invasive sensor signal, and said relationship.

17. The method of claim 16, wherein:

said processing step includes a filtering step of separating from said noninvasive sensor signal a component of one of the group consisting of said physiological parameter waveform, said received exciter waveform, signal exciter waveform and a noise waveform.

18. The method of claim 16, wherein:

said processing step includes a filtering step of separating from said noninvasive sensor signal a component having a time-varying phase.

19. The method of claim 16, wherein:

said processing step includes a filtering step of determining an arc representing time varying positions of said received exciter waveform, determining a center point of said arc and determining a noise vector from an origin to said center point; and

said processing step includes a filtering step of determining an arc vector from said center point to said time varying positions, where said arc vector has an arc vector angle that moves from a first angle to a second angle over time.

20. The method of claim 16, further comprising:

inducing a second transmitted exciter waveform into the patient; and

wherein said processing step includes a filtering step of separating from said noninvasive sensor signal a component of one of the group consisting of said physiological parameter waveform, said received exciter waveform, a second received exciter waveform, a signal exciter waveform, second signal exciter waveform and a noise waveform.

21. The method of one of claims 16, 17, 18 or 19, wherein:

said processing step includes determining a relationship between a component of said received exciter waveform and an amplitude and DC offset of the physiological parameter.

22. The method of one of claims 16, 17, 18 or 19, wherein:

said processing step includes determining a relationship between an amplitude and phase of a component of said received exciter waveform and an amplitude and DC offset of the physiological parameter.

23. The method of one of claims 16, 17, 18, 19 or 20, wherein:

said processing step includes determining the validity of said calibration signal and initiating said step of providing a calibration signal when said calibration signal is not valid.

24. The method of one of claims 16, 17, 18, 19 or 20, wherein:

said processing step includes scaling said physiological parameter waveform based on the relationship between a property of said received exciter waveform and a property of the physiological parameter and generating a scaled physiological parameter waveform signal.

25. A monitor for determining a patient'"'"'s blood pressure, comprising:

an inflatable cuff positioned on an extremity of the patient and configured to provide a calibration signal representative of the patient'"'"'s physiological parameter;

an exciter positioned over a blood vessel of the patient and configured to induce a transmitted exciter waveform into the patient;

a noninvasive sensor, positioned over said blood vessel and at a distance from said exciter, said noninvasive sensor configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of said hemoparameter containing a component of a received exciter waveform;

a processor configured to determine a relationship between a property of said received exciter waveform and a property of said physiological parameter;

wherein said processor is connected to receive said calibration signal and said noninvasive sensor signal;

wherein said processor includes a filter configured to separate from said noninvasive sensor signal a component representing said received exciter waveform; and

wherein said processor is configured to determine said physiological parameter based at least in part on said calibration signal, said noninvasive sensor signal, and said relationship.

26. The monitor of claim 25, further comprising:

an exciter sensor, positioned near said exciter and configured to sense said transmitted exciter waveform and generating an exciter sensor signal representative of said transmitted exciter waveform, and

wherein said processor is further configured to compare the phase relationship of said transmitted exciter sensor signal and said received exciter waveform to determine said blood pressure.