Programmable control mounting system for transdermal drug applicator

• US 5,591,123 A
• Filed: 01/30/1995
• Issued: 01/07/1997
• Est. Priority Date: 08/18/1983
• Status: Expired due to Term

• Current Assignee: Drug Delivery Systems Incorporated
• Original Assignee: Drug Delivery Systems Incorporated
• Inventors: Sibalis, Dan, Rosen, Sanford
• Primary Examiner(s): Prebilic, Paul B.
• Application Number:
  US08/381,141
• Time in Patent Office: 708 Days
• Field of Search: 604/20, 128/635, 128/666, 128/690, 607/149, 607/152
• US Class Current: 604/20
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin (144) into the bloodstream comprising an applicator (100) including at least one drug reservoir (182A,182B) containing the drug for delivering same through the skin (144) by physico/chemical mass transfer. A mounting structure (138, 140) is removably mounted to the body for holding the applicator (100) to the skin (144), with the applicator (100) removably connected to the mounting structure (138,140). A power supply (166) for the applicator (100) and a circuit transmitting electrical power from the power supply (166) to the applicator (100) is disclosed, wherein an electric circuit is created between the applicator (100) and the skin (144). The device includes a computer (158) with the mounting structure (138,140) for receiving programmed instructions relative to the drug, and transmitting signals relative to the drug and the programmed instructions to the power supply (166) for regulating the generation of power and delivery of drug through the skin (144).

Claims

1. A two-part replenishable drug applicator system for transdermal drug delivery of at least one drug to the systemic blood of a human being or animal through skin thereof comprising:

a reusable assembly having a computer control part of said drug applicator system removably mountable on said human or animal for control of transdermal delivery of at least one drug through the skin;

said computer control part including a source of electrical energy for electrically energizing said drug applicator system and effecting flow of current through the skin;

a drug containing cartridge comprising a replaceable drug reservoir for containing at least one drug and replaceably mountable on said computer control part in a separable assembly for replenishing said drug applicator system with at least one drug as required;

said drug reservoir having a permeable surface for contacting the skin of said human being or animal when said drug reservoir is mounted on said computer control part; and

means on said drug reservoir and means on said computer control part for cooperative association when said drug reservoir is mounted on said computer control part effectively establishing a current flow path from said computer control part to said drug reservoir and through the skin of said human being or animal for application of controlled electrical current to said drug reservoir for application of a drug through said surface thereof in contact with the skin of staid human being or animal.

2. A two-part replenishable drug applicator system according to claim 1, in which said computer control part comprises a watch body.

3. A two-part replenishable drug applicator system according to claim 1, in which said computer control part comprises a programmable computer.

4. A two-part replenishable drug applicator system according to claim 1, in which drug reservoir comprises a permeable membrane defining said surface.

5. A two-part drug applicator system according to claim 1, in which the means on said computer control part and the means on said drug reservoir comprise switch means for cooperative associate in establishing automatically said current flow path.

6. A two-part drug applicator system according to claim 1, in which said drug reservoir comprises a filling tube, and said computer control part having a bore for access to said tube extending therethrough, the tube having a puncturable self-sealing seal at an exterior end thereof for introduction of a replenishment drug into said drug reservoir with a syringe for penetrating said puncturable self-sealing seal and enabling said replenishment drug to be forced into said drug reservoir.

7. A two-part replenishable drug applicator system according to claim 1, in which said reusable assembly and said cartridge are coupled together and said cartridge underlies said computer control part of said reusable assembly when coupled thereto.