Composite artificial blood vessel

• US 5,591,225 A
• Filed: 11/23/1994
• Issued: 01/07/1997
• Est. Priority Date: 03/29/1991
• Status: Expired due to Fees

• Current Assignee: Vascular Craft Research Center Company Limited
• Original Assignee: Vascular Craft Research Center Company Limited
• Inventors: Okuda, Yasuhiro
• Primary Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US08/347,156
• Time in Patent Office: 776 Days
• Field of Search: 623/1, 623/11, 623/12, 600/36
• US Class Current: 623/1.49
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/22 Polypeptides or derivatives thereof , e.g. degradation products
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

An artificial blood vessel comprising a tube of a porous synthetic polymer on a surface of which a protein or a peptide having cell adhesion and growth functions is covalently bonded through hydroxyl groups, carboxyl groups, epoxy groups or amino groups. Its surface is uniformly composited stably with the material having the tissue induction function by the covalent bond without deforming a shape of the porous synthetic polymer material. Therefore, no initial thrombus is induced, and the intima is quickly formed and remains stably for a long time.

Claims

1. An artificial blood vessel comprising:

a tube formed from expanded polytetrafluoroethylene having a porosity of at least 70% and a pore diameter from 20 to 200 μ

m, said tube having an inner and an outer surface on which is grafted a compound having a functional group selected from the group consisting of hydroxyl, carboxyl, epoxy and amino, wherein said functional group has been introduced onto said tube by defluorinating said polytetrafluoroethylene with an alkali metal compound and grafting thereto a compound having said functional group; and

a material having cell adhesion and growth functions selected from the group consisting of proteins and peptides, covalently bonded through said functional groups to said inner and outer surfaces of said tube such that voids associated with the expanded polytetrafluoroethylene remain unclogged, and said material is present on said tube as a uniform, flexible and thin layer.

2. The artificial blood vessel according to claim 1, wherein said material having the cell adhesion function is at least one protein selected from the group consisting of collagen, gelatin, laminin and fibronectin.

3. The artificial blood vessel according to claim 1, wherein said material is gelatinized atelocollagen.

4. The artificial blood vessel according to claim 1, wherein said alkali metal compound to be used for defluorination is selected from the group comprising methyllithium, n-butyllithium or tert.-butyl-lithium, and is used in combination with hexamethylphosphoric triamide for the defluorination of polytetrafluoroethylene.

5. The artificial blood vessel according to claim 1 wherein the thin layer is characterized by an unevenness of less than 50 nm.