Self-aligning mechanism for positioning analyte receptacles

• US 5,592,289 A
• Filed: 01/09/1995
• Issued: 01/07/1997
• Est. Priority Date: 01/09/1995
• Status: Expired due to Fees

• Current Assignee: GE Healthcare SV Corp (Thermo Fisher Scientific Incorporated)
• Original Assignee: Molecular Dynamics Limited
• Inventors: Norris, Michael C.
• Primary Examiner(s): Pham, Hoa Q.
• Application Number:
  US08/370,486
• Time in Patent Office: 729 Days
• Field of Search: 356/244, 356/246, 356/440, 356/399, 250/576, 436/165, 436/809, 422/101, 422/102, 422/186, 422/109, 422/104, 359/391, 359/392, 359/396, 359/393
• US Class Current: 356/244
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: B01L 9/523 for multisample carriers, e.g. used for microtitration plates
• CPC Class Codes: G01N 21/13 Moving of cuvettes or solid samples to or from the investigating station handling materials for automatic analysis G01N35/00
• CPC Class Codes: G01N 35/028 having reaction cells in the form of microtitration plates
• CPC Class Codes: Y10S 436/809 Multifield plates or multicontainer arrays

Abstract

A self-aligning mechanism for positioning analyte receptacles comprises a loading carriage which bears a tray. In one embodiment, the carriage is slidingly mounted in a structure and includes three guide pins and a stop pin. In this embodiment, the tray has a leaf spring attached at the rear thereof, a lateral protuberance for contacting the structure, and two frontal and one lateral oblique slots. A pair of vertical contact planes, orthogonally disposed with respect to each other, are formed on the top surface of the tray.

Claims

1. A mechanism for positioning an analyte receptacle with respect to a measuring instrument, said mechanism comprising:

a carriage retractably supported in a structure, said carriage includes at least three guide members and at least one stop member, rigidly attached to said carriage; and

a tray movably coupled to said carriage, said tray comprises at least three slots capable of engaging said at least three guide members, at least one biasing device comprising a spring and being preloaded against said at least one stop member, a protuberance for contacting said structure, and a pair of contact surfaces capable of pushing said analyte receptacle against said at least three guide members, and wherein said tray is demountably coupled to said carriage, and wherein said protuberance contacts said structure when said carriage is protracted from said structure, thereby displacing said tray along said at least three guide members to provide an area for placing said analyte receptacle on said tray, said area being defined by said at least three guide members and said pair of contact surfaces.

2. The mechanism of claim 1 wherein said protuberance loses contact with said structure when said carriage is retracted into said enclosure, whereby said at least one biasing device displaces said tray along said at least three guide members such that said pair of contact surfaces pushes said analyte receptacle against said at least three guide members, thereby positioning said analyte receptacle so that its contents can be analyzed by said measuring instrument.

3. The mechanism of claim 2 wherein one of said contact surfaces contains a cavity having a compressibly preloaded contact element protruding therefrom.

4. The mechanism of claim 3 wherein said carriage further includes a first array of through openings, said tray having a second array of through openings, said analyte receptacle having a specific analyte-sample configuration, the number of the through openings in said second array corresponding to said specific analyte-sample configuration.

5. The mechanism of claim 4 wherein the through openings of said first and second arrays line up when said carriage is retracted into said enclosure, some of the through openings of said first array being blocked by said tray, resulting in a third array of through openings defining a binary code.

6. The mechanism of claim 5 wherein said carriage and said tray each have a through opening located substantially at the center thereof with nominal dimensions of said analyte receptacle and wherein said second array having fewer openings than said first array.

7. The mechanism of claim 5 wherein said carriage has a through opening located substantially at the center thereof with nominal dimensions of said analyte receptacle, said tray having an array of through openings substantially at the center thereof, said array of through openings having a configuration corresponding to said specific analyte-sample configuration of said analyte receptacle.

8. The mechanism of claim 5 further including a computer coupled to said measuring instrument, said computer stores a set of measuring-instrument instructions for reading said analyte receptacle, said set of measuring-instrument instructions comprising several subsets.

9. The mechanism of claim 8 wherein said at least one stop member and said at least three guide members comprise dowel pins.

10. The mechanism of claim 8 wherein said computer obtains said binary code by utilizing signals generated when said measuring instrument reads said third array of through openings, said computer executing a particular subset from said set of measuring-instrument instructions based on said binary code, said set of measuring-instrument instructions being stored in said computer.

11. A photometer having a mechanism for positioning an analyte receptacle with respect to said photometer, said photometer and said mechanism being coupled to a computer, said mechanism comprising:

a carriage retractably supported in a structure; and

a tray movably and demountably coupled to said carriage,

wherein said tray comprises;

three oblique slots slidingly engaging at least three guide pins on said carriage;

a spring preloaded against at least one stop pin on said carriage; and

a lateral protuberance contacting said structure when said carriage is

protracted from said structure, thereby displacing

said tray along said at least three guide pins to provide an area for placing said analyte receptacle on said tray, said area being defined by said at least three guide pins and a pair of vertical orthogonal contact surfaces formed on said tray.

12. The photometer of claim 11 wherein said lateral protuberance loses contact with said structure when said carriage is retracted into said structure, wherein said spring displaces said tray along said at least three guide pins so that said pair of vertical orthogonal contact surfaces pushes said analyte receptacle against said at least three guide pins, thereby positioning said analyte receptacle.

13. The photometer of claim 12 wherein said analyte receptacle comprises a plurality of analyte sites having a specific number and configuration, said carriage further including a first array of through openings, said tray having a second array of through openings, the number of openings in said second linear array corresponding to said specific number and configuration.

14. The photometer of claim 13 wherein the through openings of said first and second arrays line up when said carriage is retracted into said structure, some of the through openings of said first array being blocked by said tray, resulting in a third array of through openings defining a binary code.

15. The photometer of claim 14 wherein a computer obtains said binary code by utilizing the signals generated when said photometer reads said third array of through openings, said computer, based on said binary code, selecting a particular subset from an existing set of instructions for reading said analyte receptacle, said existing set of instructions being stored in said computer.

16. A method for positioning an analyte receptacle with respect to a measuring instrument, said method comprising:

disengaging a biasing device on a structure to provide an opening between a plurality of alignment surfaces;

placing said analyte receptacle on said structure;

engaging said biasing device such that alignment edges of said analyte receptacle engage said plurality of alignment surfaces.

17. A method as in claim 16 wherein said step of placing occurs without requiring a force to overcome a corresponding force produced by said biasing device.

18. A method as in claim 16 wherein said step of disengaging said biasing device comprises moving a tray relative to said structure, said tray for holding said analyte receptacle.

19. A method as in claim 18 wherein said step of engaging said biasing device comprises moving said tray relative to said structure.

20. A method as in claim 16 wherein said step of engaging said biasing device comprises moving a tray relative to said structure, said tray for holding said analyte receptacle.