Apparatus for estimating the change in an analyte from hemolysis in a fluid sample
First Claim
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1. An apparatus for estimating a change in an analyte in a blood sample which is due to the hemolysis of red blood cells comprising:
- (a) a dry separation material to which a portion of said blood sample may be applied and a remainder, said material having physical characteristics effective to separate a fraction of said sample by wicking action, which fraction would essentially be free of red blood cells but would contain a representative amount of any extracellular hemoglobin that may be present in said sample;
(b) a location in said remainder providing means for ascertaining the amount of said extracellular hemoglobin in said fraction; and
,(c) a correlation means for estimating a change in said analyte in said sample from the amount of said extracellular hemoglobin in said fraction.
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Abstract
The present invention concerns a method of detecting hemolysis in a whole-blood sample, a method of determining an elevation in the potassium ion concentration of a whole-blood sample, an apparatus for detecting hemolysis and/or determining an elevation in the potassium ion concentration in a fluid sample, an apparatus for detecting hemolysis and/or determining an elevation in the potassium ion concentration in a whole-blood sample, and a single-use cartridge containing a plurality of microfabricated biosensors which further contains a hemolysis detection unit.
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16 Claims
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1. An apparatus for estimating a change in an analyte in a blood sample which is due to the hemolysis of red blood cells comprising:
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(a) a dry separation material to which a portion of said blood sample may be applied and a remainder, said material having physical characteristics effective to separate a fraction of said sample by wicking action, which fraction would essentially be free of red blood cells but would contain a representative amount of any extracellular hemoglobin that may be present in said sample; (b) a location in said remainder providing means for ascertaining the amount of said extracellular hemoglobin in said fraction; and
,(c) a correlation means for estimating a change in said analyte in said sample from the amount of said extracellular hemoglobin in said fraction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification