Sustained release tablet
First Claim
1. A zero order dissolution sustained release tablet comprising a base tablet comprising a water-swellable gelling agent in a proportion of not less than 20% by weight per base tablet and a pharmaceutically active ingredient dispersed homogeneously in said gelling agent, said base tablet being coated with a film coating composition consisting essentially of one prepared by dissolving at least one member selected from the group consisting of ethylcellulose and acetylcellulose as a main component in an organic solvent, wherein the film coating composition is used in a proportion of 0.5-15% by weight relative to the base tablet, the thickness of the film is 0.002-0.05 mm at the side and 0.003-0.06 mm at the top or the bottom, and the ratio of the film thickness at the side to that at the top or the bottom is 0.55-0.85.
3 Assignments
0 Petitions
Accused Products
Abstract
A sustained release tablet comprising a base tablet comprising a water-swellable gelling agent and a pharmaceutically active ingredient dispersed homogeneously in said gelling agent, said base tablet being coated with a film coating composition prepared by dissolving one or two members selected from the group consisting of ethylcellulose and acetylcellulose in an organic solvent. The tablet is capable of zero order dissolution of both water-soluble drugs and slightly water-soluble drugs, and can be produced economically with ease.
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Citations
10 Claims
- 1. A zero order dissolution sustained release tablet comprising a base tablet comprising a water-swellable gelling agent in a proportion of not less than 20% by weight per base tablet and a pharmaceutically active ingredient dispersed homogeneously in said gelling agent, said base tablet being coated with a film coating composition consisting essentially of one prepared by dissolving at least one member selected from the group consisting of ethylcellulose and acetylcellulose as a main component in an organic solvent, wherein the film coating composition is used in a proportion of 0.5-15% by weight relative to the base tablet, the thickness of the film is 0.002-0.05 mm at the side and 0.003-0.06 mm at the top or the bottom, and the ratio of the film thickness at the side to that at the top or the bottom is 0.55-0.85.
- 2. A zero order dissolution sustained release tablet comprising a base tablet comprising a water-swellable gelling agent in a proportion of not less than 20% by weight per base tablet and a pharmaceutically active ingredient dispersed homogeneously in said gelling agent, said base tablet being coated with a film coating composition consisting essentially of one prepared by dissolving at least one member selected from the group consisting of ethylcellulose and acetylcellulose, and polyethylene glycol in an organic solvent, wherein the film coating composition is used in a proportion of 0.5-15% by weight relative to the base tablet, the thickness of the film is 0.002-0.05 mm at the side and 0.003-0.06 mm at the top or the bottom, and the ratio of the film thickness at the side to that at the top or the bottom is 0.55-0.85.
Specification