Use of quinoline-3-carboxamide compounds for treatment of diabetes
First Claim
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1. A method for preventing, treating or ameliorating Type I diabetes, which comprises:
- administering an effective amount of an anti-diabetic quinoline-3-carboxamide of formula I, or a pharmaceutically acceptable salt thereof, to a patient in need thereof;
##STR4## wherein ----- represents two conjugated double bonds between the atoms comprised by the dashed line, X1 and X2 are independently selected from an oxygen atom or NH9, H1-9 independently represent a hydrogen atom or a substituent, wherein H7 and H8 are attached to different atoms selected from X1, X2 and the ring nitrogen atom of the quinoline ring, said X1 and X2 being bound by a single bond to the ring when H7 or H8 is bonded thereto and by a double bond when H7 or H8 is not bonded thereto.
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Abstract
Quinoline-3-carboxamide compounds of formula (I) are effective in preventing, treating or ameliorating Type I diabetes. ##STR1## wherein ----- represents two conjugated double bonds between the atoms comprised by the dashed line, X1 and X2 are independently selected from an oxygen atom or NH9, H1-9 independently represent a hydrogen atom or a substituent, wherein H7 and H8 are attached to different atoms selected from X1, X2 and the ring nitrogen atom of the quinoline ring. In particular, X1 and X2 being bound by a single bond to the ring when H7 or H8 is bonded thereto and by a double bond when H7 or H8 is not bonded thereto.
9 Citations
9 Claims
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1. A method for preventing, treating or ameliorating Type I diabetes, which comprises:
administering an effective amount of an anti-diabetic quinoline-3-carboxamide of formula I, or a pharmaceutically acceptable salt thereof, to a patient in need thereof;
##STR4## wherein ----- represents two conjugated double bonds between the atoms comprised by the dashed line, X1 and X2 are independently selected from an oxygen atom or NH9, H1-9 independently represent a hydrogen atom or a substituent, wherein H7 and H8 are attached to different atoms selected from X1, X2 and the ring nitrogen atom of the quinoline ring, said X1 and X2 being bound by a single bond to the ring when H7 or H8 is bonded thereto and by a double bond when H7 or H8 is not bonded thereto.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for treating insulitis, which comprises administering an anti-insulitis effective amount of a quinoline-3-carboxamide compound of formula (I) to a patient in need thereof:
- ##STR5## wherein ----- represents two conjugated double bonds between the atoms comprised by the dashed line, X1 and X2 are independently selected from an oxygen atom or NH9, H1-9 independently represent a hydrogen atom or a substituent, wherein H7 and H8 are attached to different atoms selected from X1, X2 and the ring nitrogen atom of the quinoline ring, said X1 and X2 being bound by a single bond to the ring when H7 or H8 is bonded thereto and by a double bond when H7 or H8 is not bonded thereto.
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Current AssigneePharmacia AB (Pharmacia Corp.)
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Original AssigneePharmacia AB (Pharmacia Corp.)
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InventorsGross, David, Slavin, Shimon, Weiss, Lola
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Primary Examiner(s)Weddington, Kevin E.
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Application NumberUS08/313,302Time in Patent Office753 DaysField of Search514/311, 514/312, 514/866, 514/884US Class Current514/311CPC Class CodesA61K 31/47 Quinolines; IsoquinolinesA61P 3/08 for glucose homeostasis pan...A61P 3/10 for hyperglycaemia, e.g. an...C07D 215/54 attached in position 3C07D 215/56 with oxygen atoms in positi...
