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Treatment of climacteric disorders with nitric oxide synthase substrates and/or donors

  • US 5,595,970 A
  • Filed: 11/16/1993
  • Issued: 01/21/1997
  • Est. Priority Date: 07/16/1993
  • Status: Expired due to Term
First Claim
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1. A method of treating climacterium (climacteric symptoms) in a non-pregnant female mammal suffering from menopausal symptoms of climacterium, exhibiting climacteric symptoms, or who is a candidate for hormone replacement therapy, comprisingadministering to said female mammalan amount of nitric oxide synthase substrate, a nitric oxide donor, or both, effective to raise the blood level of circulating L-arginine to at least about 10-50 nmolar above the normally 50-100 nmolar circulating levels and,optionally, also a progestin or both of an estrogen and a progestin, in amounts effective to ameliorate the symptoms thereof.

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