Coronary sinus reperfusion catheter

• US 5,597,377 A
• Filed: 05/06/1994
• Issued: 01/28/1997
• Est. Priority Date: 05/06/1994
• Status: Expired due to Fees

• Current Assignee: Trustees of Boston University
• Original Assignee: Trustees of Boston University
• Inventors: Aldea, Gabriel S.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): SMITH, CHALIN A
• Application Number:
  US08/238,860
• Time in Patent Office: 998 Days
• Field of Search: 128/637, 604/27, 604/28, 604/31, 604/53, 604/43, 604/45, 604/93, 604/118, 604/264, 600/16, 600/17
• US Class Current: 600/16
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61M 1/3613 Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions

Abstract

A catheter for retroperfusion of myocardium has an infusion tip, such that when retroperfusing myocardium, the tip extends within the coronary sinus to a depth in a range of about 2 to 4 inches (5 to 10 cm) from the coronary sinus ostium. The catheter also comprises a tube defining at least three channels. The channels include an infusion channel, which has a first infusion end coupled to an infusion port located in the infusion tip and a second infusion end coupled to an outlet orifice of a pump; a withdrawal channel, which has a first withdrawal end coupled to a withdrawal port located in the superior vena cava and a second withdrawal end coupled to an inlet orifice of the pump; and a pressure monitoring channel for monitoring pressure at pressure port at the infusion tip having a first monitoring end coupled to the pressure port and a second monitoring end coupled to a pressure sensor. The catheter also has a microprocessor for controlling the pump and measuring a rate of retroperfusate flow, whereby autologous venous blood entering the withdrawal port is continuously discharged at the infusion port at a flow rate in a range of about 5 to 50 mil./min. and at a pressure less than about 15 mm Hg. The tube and tip are made from biocompatible, non-thrombogenic material. Further, the catheter has remotely identifiable markers spaced along the tube, and a marker is located at said infusion tip. The invention also is a method for coronary sinus retroperfusion. The method includes the steps of inserting the catheter through the patient'"'"'s jugular vein; guiding the catheter'"'"'s infusion tip into the coronary sinus, such that when retroperfusing myocardium, the tip extends within the coronary sinus to a depth in a range of about 2 to 4 inches (5 to 10 cm) from the coronary sinus ostium; and providing a non-synchronized retroperfusate flow of autologous venous blood at a rate in a range of about 5 to 50 mil./min. and at a pressure less than about 15 mm Hg.

Claims

1. A non-occluding catheter for retroperfusion of tissue having a defined systemic vein, said vein draining blood from said tissue through a venous junction coupling said vein to the greater circulatory system, comprising:

a non-occluding infusion tip, such that when retroperfusing said tissue with a retroperfusate flow, said tip is extends within said vein to a depth in a range of about 2 to 4 inches (5.08 to 10.16 cm) from said venous junction and does not occlude said vein, such that said blood continues to flow from said vein;

a pump having an inlet orifice and an outlet orifice;

a tube defining a plurality of channels including at least one withdrawal channel, each of which has a first withdrawal end, a withdrawal port, and a second withdrawal end, wherein said first withdrawal end is coupled to said withdrawal port and said second withdrawal end is coupled to said inlet orifice of said pump;

at least one infusion channel, each of which has a first infusion end, an infusion port located in said infusion tip, and a second infusion end, wherein said first infusion end is coupled to said infusion port and said second infusion end is coupled to said outlet orifice of said pump; and

a pressure monitoring channel for monitoring pressure at a pressure port at said infusion tip having a first monitoring end, a second monitoring end, and a pressure sensor, wherein said first monitoring end is coupled to said pressure port and said second monitoring end is coupled to said pressure sensor; and

means for controlling said pump having a flowmeter for measuring a rate of said retroperfusate flow, whereby fluid entering said withdrawal port is discharged at said infusion port at a flow rate in a range of about 5 to 50 mil./min. and at a pressure less than about 15 mm Hg, said tube and tip made from biocompatible, non-thrombogenic material.

2. A coronary sinus retroperfusion non-occluding catheter for retroperfusion of myocardium, comprising:

a non-occluding infusion tip, such that when retroperfusing myocardium with a retroperfusate flow, said tip extends within the coronary sinus to a depth in a range of about 2 to 4 inches (5.08 to 10.16 cm) from the coronary sinus ostium and does not occlude the coronary sinus, such that said blood continues to flow from the coronary sinus;

a pump having an inlet orifice and an outlet orifice;

a tube defining a plurality of channels including at least one withdrawal channel, each of which has a first withdrawal end, a withdrawal port, and a second withdrawal end, wherein said first withdrawal end is coupled to said withdrawal port and said second withdrawal end is coupled to said inlet orifice of said pump;

at least one infusion channel, each of which has a first infusion end, an infusion port located in said infusion tip, and a second infusion end, wherein said first infusion end is coupled to said infusion port and said second infusion end is coupled to said outlet orifice of said pump; and

a pressure monitoring channel for monitoring pressure at a pressure port at said infusion tip having a first monitoring end, a second monitoring end, and a pressure sensor, wherein said first monitoring end is coupled to said pressure port and said second monitoring end is coupled to said pressure sensor; and

means for controlling said pump having a flowmeter for measuring a rate of said retroperfusate flow, whereby fluid entering said withdrawal port is discharged at said infusion port at a flow rate in a range of about 5 to 50 mil./min. and at a pressure less than about 15 mm Hg, said tube and tip made from biocompatible, non-thrombogenic material.

3. The catheter of claim 2, further comprising at least one reservoir containing a pharmaceutical agent and an agent infusion port located in said infusion tip, wherein said tube further defines at least one pharmaceutical agent delivery channel, each of which has a delivery end, a source end, and a delivery means, wherein said delivery end is coupled to said agent infusion port and said source end is coupled to said delivery means for providing a measured flow of said pharmaceutical agent from said reservoir.

4. The catheter of claim 2, wherein said at least one withdrawal port is located at a distance in a range of about 8 to 10 inches (20.32 to 25.4 cm) from said infusion port and positioned in the superior vena cava and said retroperfusate flow is an autologous sanguinous solution.

5. The catheter of claim 2, wherein said sanguinous solution is venous blood.

6. The catheter of claim 2, wherein said rate of retroperfusate flow is about 10 mil./min.

7. The catheter of claim 2, wherein said tube made with a treatment selected from the group consisting of a heparin bonding treatment and a hirudin bonding treatment.

8. The catheter of claim 2, wherein said tip further comprises a monitoring device to measure a parameter selected from the group consisting of intravascular blood pH and blood oximetry.

9. The catheter of claim 2, wherein said pump is an intravenous infusion pump.

10. The catheter of claim 2, wherein said pump includes a micromotor and is housed within said tube.

11. The catheter of claim 2, wherein each of said withdrawal channels and said infusion channels includes a vent for purging gases from said at least one withdrawal channel and said at least one infusion channel, respectively.

12. The catheter of claim 2, wherein said retroperfusate flow is an extrinsic asanguinous solution.

13. The catheter of claim 12, wherein said asanguinous solution is a myocardial tissue enhancement solution.

14. The catheter of claim 2, further comprising a plurality of depth markers spaced along said tube and at least one of said markers located at said infusion tip.

15. The catheter of claim 14, wherein each of said depth markers is fluoroscopically opaque, whereby said markers are remotely identifiable.

16. The catheter of claim 14, wherein each of said depth markers has a distinctive echocardiographic signature, whereby said markers are remotely identifiable.

17. The catheter of claim 14, wherein said depth markers spaced about 2 inches (5.08 cm) apart along said tube.