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Method of formulating IGF-I with growth hormone

  • US 5,597,802 A
  • Filed: 06/02/1995
  • Issued: 01/28/1997
  • Est. Priority Date: 06/07/1990
  • Status: Expired due to Term
First Claim
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1. A process for preparing a formulation comprising mixing an IGF-I-containing composition comprising about 2-20 mg/ml of IGF-I, about 2-50 mg/ml of an osmolyte, about 1-15 mg/ml of a stabilizer, and a buffered solution at about pH. 5-5.5 with a buffered solution comprising growth hormone at pH about 6 in a dose (mg) ratio of from about 2:

  • 1 to 100;

    1 IGF-I;

    growth hormone up to a dose no greater than about 5 mg/ml of growth hormone.

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