Blood flow measurement system

• US 5,598,841 A
• Filed: 09/15/1994
• Issued: 02/04/1997
• Est. Priority Date: 09/24/1993
• Status: Expired due to Fees

• Current Assignee: KOWA Company Limited
• Original Assignee: KOWA Company Limited
• Inventors: Katayama, Koji, Taniji, Ayafumi, Takanashi, Satohiko
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/306,379
• Time in Patent Office: 873 Days
• Field of Search: 128/633-634, 128/664-666, 128/691, 356/39-41
• US Class Current: 600/342
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/6876 Blood vessel
• CPC Class Codes: A61B 5/6884 Clamps or clips
• CPC Class Codes: A61B 5/7253 characterised by using transforms
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

A blood flow measurement system for measuring blood flow rate and blood flow velocity comprises a circuit device for irradiating an in vivo tissue measurement subject with coherent light, a light receiving element for receiving scattered light from the in vivo tissue, a converter for converting an intensity of the received scattered light into an electric signal, a circuit device for calculating a power spectrum of the time-course variation of the scattered light intensity, a device for plotting the power spectrum in a semilogarithmic coordinate system having a logarithmic vertical axis, and a device for linearly approximating a prescribed frequency component of the semilogarithmic power spectrum and calculating a slope and a y intercept of the power spectrum curve. The blood flow velocity can be determined from the slope of the curve approximating the power spectrum, while blood flow rate can be determined from the slope and y intercept of the curve approximating the power spectrum.

Claims

1. A blood flow measurement system for measuring blood flow rate and blood flow velocity comprising:

means for irradiating a in vivo tissue measurement subject with coherent light;

means for receiving scattered light from the in vivo tissue;

means for converting an intensity of the received scattered light into an electrical signal;

means for calculating a power spectrum of the time-course variation of the scattered light intensity based on the electrical signal;

means for plotting the power spectrum in a semilogarithmic coordinate system having a logarithmic vertical axis;

means for linearly approximating a prescribed frequency component of the semilogarithmic power spectrum and calculating a slope and a y intercept of the power spectrum curve; and

means for calculating blood flow velocity from the slope of the curve approximating the power spectrum and calculating the blood flow rate from the slope and y intercept of the curve approximating the power spectrum.

2. A blood flow measurement system according to claim 1, wherein:

the irradiating means includes means for repeatedly spatially scanning a prescribed two-dimensional plane on the in vivo tissue measurement subject with the coherent light and momentarily stopping the coherent light to measure at a plurality of prescribed measurement points in the two-dimensional plane;

the means for receiving scattered light receives scattered light from the plurality of measurement points;

the means for converting the intensity of the received scattered light into an electrical signal measures the time-course variation of the scattered light intensity at each measurement point;

the means for calculating a power spectrum comprises a Fourier transform circuit for Fourier transforming the time-course variation;

the plotting means calculates a semilogarithmic power spectrum whose vertical axis is scaled logarithmically and whose frequency axis is scaled arithmetically;

the linear approximating means approximates a component of the power spectrum linearly above several hundred Hz and calculates the slope and y intercept of the approximated power spectrum; and

the means for calculating the blood flow velocity and the blood flow rate calculates the blood flow velocity and the blood flow rate at the plurality of measurement points.

3. A blood flow measurement system according to claim 1, wherein:

the irradiating means includes means for irradiating a prescribed point on the in vivo tissue measurement subject with the coherent light;

the means for receiving scattered light receives scattered light from the prescribed point;

the means for converting the intensity of the received scattered light into an electrical signal measures the time-course variation of the scattered light intensity at the prescribed point;

the means for calculating a power spectrum comprises a Fourier transformation circuit for Fourier transforming the time-course variation;

the plotting means calculates a semilogarithmic power spectrum whose vertical axis is scaled logarithmically and whose frequency axis is scaled arithmetically;

the linear approximating means approximates a component of the power spectrum linearly above several hundred Hz and calculates the slope and y intercept of the approximated power spectrum curve; and

the means for calculating the blood flow velocity and the blood flow rate calculates the blood flow velocity and the blood flow rate at the prescribed point from the calculated slope and y intercept.

4. A blood flow measurement system according to claim 1;

further comprising a measurement probe having means for maintaining the diameter of a blood vessel of the in vivo tissue constant; and

wherein;

the irradiating means irradiates the blood vessel with the coherent light;

the means for receiving scattered light receives scattered light from erythrocytes in the blood vessel;

the means for converting the intensity of the received scattered light into an electrical signal includes means for photoelectrically converting the scattered light received from the erythrocytes into a scattered light intensity variation electrical signal;

the means for calculating a power spectrum comprises a Fourier transform circuit for Fourier transforming the scattered light intensity variation electrical signal;

the plotting means calculates a semilogarithmic power spectrum whose vertical axis is scaled logarithmically and whose frequency axis is scaled arithmetically;

the linear approximating means approximates a component of the power spectrum above several hundred Hz and calculates the slope and y intercept of the approximated power spectrum curve; and

the means for calculating the blood flow velocity and the blood flow rate calculates the blood flow velocity from the slope and calculates the blood flow rate from the blood flow velocity and a sectional area of the blood vessel determined from the constant blood vessel diameter maintained by the measurement probe.

5. A blood flow measurement system according to claim 1;

wherein the linear approximating means comprises a fast Fourier transform circuit for calculating a scattered light intensity variation signal power spectrum and calculating the semilogarithmic power spectrum, the y intercept and slope of the semilogarithmic power spectrum curve being calculated by a method of least squares.

6. A blood flow measurement system according to claim 5;

wherein

the linear approximating means includes means for calculating an upper limit of the semilogarithmic power spectrum linear approximating region to a value higher than a signal intensity equal to the sum of a prescribed multiple of a standard deviation of the signal intensity in a prescribed high-frequency region where the signal density is flat and an average of the same signal intensity.

7. A blood flow measurement system according to claim 1;

further comprising at least two sets each consisting of a band-pass filter, an effective value deriving circuit and a logarithmic converter, the band-pass filters of different sets having different band frequencies; and

wherein

the linear approximating means approximates a component of the semilogarithmic power spectrum curve above 500 Hz based on the outputs obtained by passing the scattered light intensity variation signal obtained through the at least two sets.

8. A blood flow measurement system for measuring blood flow rate and blood flow velocity comprising:

means for irradiating an in vivo tissue measurement subject with coherent light;

means for receiving scattered light from the in vivo tissue;

means for converting an intensity of the received scattered light into an electrical signal;

first calculating means for calculating a power spectrum of the time-course variation of the scattered light intensity based on the electrical signal;

means for exponentially approximating frequency components of the power spectrum above several hundred Hz and calculating a 1/e width and a DC intensity of the power spectrum; and

second calculating means for calculating the blood flow velocity from the 1/e width of the power spectrum and calculating the blood flow rate from the 1/e width and the DC intensity obtained by exponential approximation of the power spectrum.

9. A blood flow measurement system according to claim 8, wherein:

the irradiating means includes means for repeatedly spatially scanning a prescribed two-dimensional plane on the in vivo tissue measurement subject with the coherent light and momentarily stopping the coherent light to measure at a plurality of prescribed measurement points in the two-dimensional plane;

the means for receiving scattered light receives scattered light from the plurality of measurement points;

the means for converting the intensity of the received scattered light into an electrical signal measures the time-course variation of the scattered light intensity at each measurement point;

the means for calculating a power spectrum comprises a Fourier transform circuit for Fourier transforming the time-course variation; and

the means for calculating the blood flow velocity and the blood flow rate calculates the blood flow velocity and the blood flow rate at the plurality of measurement points.

10. A blood flow measurement system according to claim 8, wherein:

the irradiating means includes means for irradiating a prescribed point on the in vivo tissue measurement subject with the coherent light;

the means for receiving scattered light receives scattered light from the prescribed point;

the means for converting the intensity of the received scattered light into an electrical signal measures the time-course variation of the scattered light intensity at the prescribed point;

the means for calculating a power spectrum comprises a Fourier transform circuit for Fourier transforming the time-course variation; and

the means for calculating the blood flow velocity and the blood flow rate calculates the blood flow velocity and blood flow rate at the prescribed point from the slope and y intercept of the power spectrum curve.

11. A blood flow measurement system according to claim 8;

further comprising a measurement probe having means for maintaining the diameter of a blood vessel of the in vivo tissue constant; and

wherein;

the irradiating means irradiates the blood vessel with the coherent light;

the means for converting the intensity of the received scattered light into an electrical signal includes means for photoelectrically converting the scattered light received from the erythrocytes into a scattered light intensity variation electrical signal;

the means for calculating a power spectrum comprises a Fourier transform circuit for Fourier transforming the scattered light intensity variation electrical signal; and

the means for calculating the blood flow velocity and the blood flow rate calculates the blood flow velocity from the 1/e width and calculates the blood flow rate from the blood flow velocity and a sectional area of the blood vessel determined from the constant blood vessel diameter maintained by the measurement probe.

12. A blood flow measurement system according to claim 8;

wherein the exponential approximating means comprises a Fourier transform circuit for calculating a power spectrum, the DC intensity and 1/e width of the exponential function being calculated by a method of least squares.

13. A blood flow measurement system according to claim 8;

further comprising at least two sets each consisting of a band-pass filter, an effective value deriving circuit and a logarithmic converter, the band-pass filters of different sets having different band frequencies; and

wherein

the exponential approximating means approximates the power spectrum based on the outputs obtained by passing the scattered light intensity variation signal obtained through the at least two sets.

14. A blood flow measurement system according to claim 8;

wherein the exponential approximating means includes means for approximating a logarithm of the calculated power spectrum by a method of least squares to a straight line whose slope and y intercept are respectively used to determine the 1/e width and DC intensity of the power spectrum.

15. A blood flow measurement system according to claim 14;

wherein the linear approximating means includes means for calculating an upper limit of the approximation region to a value higher than a signal intensity equal to the sum of a predetermined multiple of a standard deviation of the signal intensity in a predetermined high-frequency region where the signal density is flat and an average of the same signal intensity.

16. A blood flow measurement system according to claim 8;

wherein the exponential approximating means includes means for extracting first and second frequency components of the power spectrum and converting the first and second frequency components to logarithmic values to determine a straight line whose slope and y intercept are respectively used to determine the 1/e width and DC intensity of the power spectrum.

17. A blood flow measurement system according to claim 8;

wherein the irradiating means includes means for repeatedly spatially scanning the coherent light in a two-dimensional plane on the in vivo tissue measurement subject and momentarily stopping the coherent light at a plurality of predetermined measurement points to measure the time-course variation of the scattered light intensity.

18. A blood flow measurement system according to claim 8;

wherein the irradiating means includes means for irradiating the coherent light on a predetermined point on the in vivo tissue measurement subject, and the receiving means receives the scattered light from the predetermined point to measure the time-course variation of its intensity.

19. A blood flow measurement system according to claim 8;

wherein the irradiating means includes means for irradiating the coherent light on a predetermined point on a blood vessel of the in vivo tissue measurement subject, and the receiving means receives the scattered light from the predetermined point to measure the time-course variation of its intensity.

20. A blood flow measurement system according to claim 8;

wherein the irradiating means includes means for irradiating a single blood vessel of the in vivo tissue measurement region with coherent light of two or more wavelengths, the first calculating means calculates the power spectrum for each wavelength, and the exponential approximating means approximates the power spectrum to the exponential function, the approximated power spectrum of one wavelength being used to determine the blood flow velocity and blood flow rate and combined with the approximated power spectrum of another wavelength to determine the degree of oxygen saturation of the single blood vessel.

21. A blood flow measurement system comprising:

means for irradiating a single blood vessel with coherent light of at least two wavelengths;

means for receiving scattered light of each wavelength from erythrocytes in the blood vessel;

at least one measurement probe having means for maintaining the diameter of the blood vessel constant;

means for photoelectrically converting the scattered light of each wavelength from the erythrocytes into a scattered light intensity variation electrical signal;

means for calculating a power spectrum of the scattered light intensity variation electrical signal by Fourier transform;

means for plotting a semilogarithmic power spectrum whose vertical axis is scaled logarithmically and whose frequency axis is scaled arithmetically;

means for linearly approximating a component of the power spectrum above several hundred Hz and calculating the slope and y intercept of the approximated power spectrum curve; and

means for calculating blood flow velocity from the slope of the curve approximating the power spectrum, calculating blood flow rate from the blood flow velocity and a sectional area of the blood vessel determined from the constant blood vessel diameter maintained by the measurement probe, and calculating the degree of oxygen saturation by calculating an absorption degree for each wavelength by comparing integrated intensities calculated from the product of the slopes and the y intercepts of the power spectrums at the two wavelengths.