Bodily sample collection balloon catheter method

• US 5,599,298 A
• Filed: 12/30/1993
• Issued: 02/04/1997
• Est. Priority Date: 12/30/1993
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Corporation
• Inventors: Sahatjian, Ronald A.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): Stright, Jr., Ronald K.
• Application Number:
  US08/175,791
• Time in Patent Office: 1,132 Days
• Field of Search: 604/49,52,53-55, 604/265, 604/96, 128/898, 128/749, 128/752, 128/758, 128/759, 128/760, 128/763, 128/765, 128/756, 128/757, 606/159, 606/160, 606/194
• US Class Current: 604/540
• CPC Class Codes: A61B 10/04 Endoscopic instruments
• CPC Class Codes: A61M 2025/109 having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

Treating a patient by collecting a bodily sample from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a polymer on its outer surface capable of receiving a substantial amount of bodily sample. The catheter is positioned within the body and the sample is taken by exposing the polymer by placing it in proximity within a desired location so that said bodily sample is received by the polymer. The catheter is removed from the patient and the sample is collected outside the body.

Claims

1. A method for taking a bodily sample from a blood vessel of a patient and collecting said sample outside the body, comprising:

providing a sampling probe in the form of an elongate vascular catheter having a proximal portion that remains outside the body and a distal portion that can be located in the blood vessel, said distal portion including an expandable portion that can be selectively expanded to larger diameters and contracted to smaller diameters, said expandable portion including a polymer on its outer surface capable of receiving a substantial amount of bodily sample suitable for detecting disease or monitoring a treatment,

positioning said expandable portion at a desired location within said blood vessel, and

taking said sample by expanding said expandable portion to contact the wall Of said blood vessel with said polymer with sufficient force to compress said polymer to a reduced thickness,

contracting said expandable portion to re-expand said polymer and draw said sample into said polymer by suction forces created by said re-expansion,

further contracting said expandable portion to smaller diameter so that said polymer does not contact said wall of said blood vessel,

removing said catheter from said patient,

collecting said sample outside the body, and

analyzing said sample to detect disease or monitor said treatment.

2. The method of claim 1 wherein said polymer is a hydrogel.

3. The method of claim 2

wherein said vascular catheter is in the form of an angioplasty catheter, said expandable portion being in the form of an inflatable balloon, said hydrogel being disposed as a coating over said balloon.

4. The method of claim 3 comprising:

positioning said expandable portion adjacent an occlusion in said vessel,

expanding said occlusion and collecting said sample by said contacting of said expandable portion.

5. The method of claim 3 comprising:

performing angioplasty on region of the blood vessel having an occlusion,

after angioplasty, positioning the expandable portion adjacent to the region, and

collecting the sample from the region.

6. The method of claim 1 comprising:

removing said sample from said polymer prior to said analyzing.

7. The method of claim 1 comprising:

removing said sample by flushing said polymer with aqueous solution.

8. The method of claim 1, wherein said polymer includes a chemical probe for preferentially binding a target component.

9. A method for taking a bodily sample from a blood vessel of a patient and collecting said sample outside the body, comprising:

providing a sampling probe in the form of an elongate vascular catheter having a proximal portion that remains outside the body and a distal portion that can be located in the blood vessel, said distal portion including an expandable portion that can be selectively expanded to larger diameters and contracted to smaller diameters, said expandable portion including a hydrogel on its outer surface capable of receiving a substantial amount of bodily sample suitable for detecting disease or monitoring a treatment,

positioning said expandable portion at a desired location within said blood vessel, and

taking said sample by exposing said hydrogel by expanding said expandable portion sufficient to place said hydrogel in proximity with the wall of said blood vessel so that said bodily sample is received by said hydrogel,

contracting said expandable portion to a smaller diameter so that said hydrogel does not contact said wall of said blood vessel,

removing said catheter from said patient,

collecting said sample outside the body, and

analyzing said sample to detect disease or monitor said treatment.

10. The method of claim 9 comprising:

introducing said catheter into said blood vessel while said hydrogel is in a substantially nonswelled state, and

collecting said sample by absorption into said hydrogel as said hydrogel swells during exposure.

11. The method of claim 10 comprising:

providing a sheath that can be positioned over said expandable portion to limit exposure of said hydrogel prior to positioning at said desired location, and

exposing said expandable portion from said sheath after positioning at said desired location.

12. The method of claims 2 or 11 comprising:

providing a sheath that can be positioned over said expandable portion after collecting said sample to reduce exposure of said hydrogel while removing said catheter from said patient.

13. The method of claim 9 comprising:

introducing said catheter into said blood vessel while said hydrogel is in a substantially nonswelled state, and

collecting said sample by absorption into said hydrogel as said hydrogel swells during exposure.

14. The method of claim 13 comprising:

providing a sheath that can be positioned over said expandable portion to limit exposure of said hydrogel prior to positioning at said desired location, and

exposing said expandable portion from said sheath after positioning at said desired location.

15. The method of claims 14 comprising:

providing a sheath that can be positioned over said expandable portion after collecting said sample to reduce exposure of said hydrogel while removing said catheter from said patient.

16. The method of claim 9, wherein said vascular catheter is in the form of an angioplasty catheter, said expandable portion being in the form of an inflatable balloon, said hydrogel being disposed as a coating over said balloon.

17. The method of claim 16 comprising:

positioning said expandable portion adjacent an occlusion in said vessel,

simultaneously expanding said occlusion and collecting said sample by expanding said expandable portion.

18. The method of claim 16 comprising:

performing angioplasty on a region of the blood vessel having an occlusion,

after angioplasty, positioning the expandable portion adjacent to the region, and

collecting the sample from the region.

19. The method of claim 9 comprising:

removing said sample from said hydrogel prior to said analyzing.

20. The method of claim 19 comprising:

removing said sample by flushing said hydrogel with aqueous solution.

21. The method of claim 9 comprising:

moving said catheter axially while said hydrogel is in contact with said wall of said vessel to brush said hydrogel along said wall to collect said sample, wherein said sample is taken without excessive mechanical disturbance to said wall of said blood vessel.

22. The method of claim 9, wherein said hydrogel includes a chemical probe for preferentially binding a target component.

23. A method for treating a patient by taking a bodily tissue sample from deep within the body of a patient and collecting said sample outside the body to facilitate treatment of the patient, comprising:

providing a sampling probe in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body, said distal portion including an expandable portion that can be selectively expanded to larger diameters and contracted to smaller diameters, said expandable portion including a polymer on its outer surface capable of receiving a substantial amount of said sample suitable for detecting disease or monitoring a treatment,

positioning said catheter within the body, and taking said sample by expanding said expandable portion to contact said bodily tissue with said polymer with sufficient force to compress said polymer to a reduced thickness,

contracting said expandable portion to re-expand said polymer and draw said sample into said polymer by suction forces created by said re-expansion,

removing said catheter from said patient,

collecting said sample outside the body, and

analyzing said sample to detect disease or monitor said treatment.

24. The method of claim 23 wherein said polymer is a hydrogel.

25. A method for treating a patient by taking a bodily tissue sample from deep within the body of a patient and collecting said sample outside the body to facilitate treatment of the patient, comprising:

providing a sampling probe in the form of an elongate vascular catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body, said distal portion including an expandable portion that can be selectively expanded to larger diameters and contracted to smaller diameters, said expandable portion including a hydrogel on its outer surface capable of receiving a substantial amount of bodily sample suitable for detecting disease or monitoring a treatment,

positioning said expandable portion at a desired location within the body, and

taking said sample by exposing said hydrogel by expanding said expandable portion sufficient to place said hydrogel in proximity with said bodily tissue so that said bodily sample is received by said hydrogel,

contracting said expandable portion to a smaller diameter so that said hydrogel does not contact said bodily tissue,

removing said catheter from said patient,

collecting said sample outside the body, and

analyzing said sample to detect disease or monitor said treatment.