Oligonucleotides having phosphorothioate linkages of high chiral purity
First Claim
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1. An oligonucleotide represented by SEQ ID NO:
- 6 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
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Abstract
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis.
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Citations
6 Claims
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1. An oligonucleotide represented by SEQ ID NO:
- 6 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (3, 5)
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2. An oligonucleotide represented by SEQ ID NO:
- 6 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (4, 6)
Specification