Non-invasive quantification of glucose control, aging, and advanced maillard products by stimulated fluorescence
First Claim
1. A non-invasive, blood chemistry measurement apparatus for measuring a concentration of a selected blood component within a sample of blood, said apparatus comprising:
- a source of light in the wavelength range from 200-600 nm, whereby this light can pass through a person'"'"'s epidermis without undue absorption by the epidermis;
means for detecting light that is emitted from molecules of the selected blood component in response to light from said source of light; and
means, responsive to said means for detecting, for calculating a concentration of said selected blood component.
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Abstract
An apparatus for measuring the concentration of selected solute in a solution. This apparatus is particulary suitable for measuring the concentration of blood components, such as blood late Maillard products. A beam of exposing light is imaged through a wall of a containment vessel onto a region of the sample adjacent to this wall to induce from said selected solute emission of light that includes at least one emission peak that can be used to calculate the concentration of this solute. At least one detector is positioned to maximize the strength of detected signal, if other components of this solution strongly absorb the emitted light. The exposing light is directed such that the detected signal is maximized as a function of the path of this exposing light. A particular embodiment is a low-cost, non-invasive blood Maillard products concentration detector. In this embodiment, the containment vessel is preferably one of the patient'"'"'s fingers. At least two additional detected signals are monitored and processed at wavenumbers suitable for eliminating temperatures and pressure effects on the calculated blood glucose levels.
122 Citations
18 Claims
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1. A non-invasive, blood chemistry measurement apparatus for measuring a concentration of a selected blood component within a sample of blood, said apparatus comprising:
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a source of light in the wavelength range from 200-600 nm, whereby this light can pass through a person'"'"'s epidermis without undue absorption by the epidermis; means for detecting light that is emitted from molecules of the selected blood component in response to light from said source of light; and means, responsive to said means for detecting, for calculating a concentration of said selected blood component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification