Beat frequency ultrasonic microsphere contrast agent detection system

• US 5,601,086 A
• Filed: 05/12/1995
• Issued: 02/11/1997
• Est. Priority Date: 05/12/1995
• Status: Expired due to Fees

• Current Assignee: National Aeronautics and Space Administration (Government of the United States of America)
• Original Assignee: United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration
• Inventors: Cantrell, John H. Jr., Yost, William T., Pretlow, Robert A. III
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US08/440,266
• Time in Patent Office: 641 Days
• Field of Search: 128/660.02, 128/662.01, 128/662.02, 73/861.25
• US Class Current: 600/458
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: G01S 15/8952 using discrete, multiple frequencies
• CPC Class Codes: G01S 7/52038 involving non-linear properties of the propagation medium or of the reflective target

Abstract

A system for and method of detecting and measuring concentrations of an ultrasonically-reflective microsphere contrast agent involving detecting non-linear sum and difference beat frequencies produced by the microspheres when two impinging signals with non-identical frequencies are combined by mixing. These beat frequencies can be used for a variety of applications such as detecting the presence of and measuring the flow rates of biological fluids and industrial liquids, including determining the concentration level of microspheres in the myocardium.

Claims

1. An apparatus for detecting the presence of ultrasonically relative microsphere contrast agents in a fluid, comprising:

means for directing ultrasonic energy into a region of the fluid at a first discrete frequency, the first frequency being approximately at a resonant frequency of the microspheres in the range of 1 MHz-30 MHz;

means for simultaneously directing ultrasonic energy into the region of fluid at a second discrete frequency that is also an approximate resonant frequency of the microspheres, wherein the microspheres in the fluid interact to emit sum and difference frequencies; and

means for detecting the sum and difference frequencies.

2. The apparatus of claim 1 wherein the directing means for the ultrasonic energy at the first frequency is a transducer.

3. The apparatus of claim 2 wherein the directing means for the ultrasonic energy at the second frequency is a transducer.

4. The apparatus of claim 3 wherein the detecting means is a receive transducer.

5. An apparatus for measuring the presence of ultrasonically reflective microsphere contrast agents in a living body fluid, comprising:

means for injecting microbubble contrast agents into a living body;

means for directing ultrasonic energy into a region of the body fluid at a first discrete frequency, the first frequency being approximately at a resonant frequency of the microspheres in the range of 1 MHz-30 MHz;

means for simultaneously directing ultrasonic energy into the region of body fluid at a second discrete frequency that is also an approximate resonant frequency of the microspheres, wherein the microspheres interact to emit sum and difference frequencies; and

means for detecting the sum and difference frequencies.

6. The apparatus of claim 5 wherein the directing means for the ultrasonic energy at the first frequency is a transducer.

7. The apparatus of claim 6 wherein the directing means for the ultrasonic energy at the second frequency is a transducer.

8. The apparatus of claim 7 wherein the detecting means is a receive transducer.

9. An method for detecting the presence of ultrasonically reflective microsphere contrast agents in a fluid, comprising:

directing ultrasonic energy into a region of the fluid at a first frequency, the first discrete frequency being approximately at a resonant frequency of the microspheres in the range of 1 MHz-30 MHz;

simultaneously directing ultrasonic energy in to the region of fluid at a second discrete frequency that is also an approximate resonant frequency of the microspheres, wherein the microspheres in the fluid interact to emit sum and difference frequencies; and

detecting the sum and difference frequencies.

10. A method for detecting the presence of ultrasonically reflective microsphere contrast agents in a body fluid, comprising the steps of:

injecting microbubble contrast agents into a living body;

directing ultrasonic energy into a region of the body fluid at a first discrete frequency, the first frequency being approximately at a resonant frequency of the microspheres in the range of 1 MHz-30 MHz;

simultaneously directing ultrasonic energy into the body fluid region at a second discrete frequency that is also an approximate resonant frequency of the microspheres, such that the microspheres interact to emit sum and difference frequencies; and

detecting the mixed frequencies generated by interaction of the resonant microspheres with ultrasonic energy at the first and second frequencies.

11. A method for detecting the presence of ultrasonically reflective microsphere contrast agents in a body fluid as in claim 10 wherein said means for injecting microbubble contrast agents further comprise a means for injecting albumin-coated microbubble contrast agents.