Method and apparatus for providing enhanced 2:1 block response with rate-responsive AV delay in a pacemaker

• US 5,601,613 A
• Filed: 02/07/1995
• Issued: 02/11/1997
• Est. Priority Date: 02/07/1995
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Medlin, Roy B., Florio, Joseph J.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/385,023
• Time in Patent Office: 735 Days
• Field of Search: 607/9, 607/14, 607/15
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

An implantable dual-chamber pacemaker programmed to operate primarily in an atrial tracking mode is provided, where the pacemaker maintains a consistent atrial rate of entry into, and exit from, a 2:1 block response mode by setting rate-responsive AV delay values in accordance with a continually monitored intrinsic atrial rate incorporating atrial events occurring during atrial refractory periods. The atrial rate of entry into, and exit from the 2:1 block response mode is determined by the length of a total atrial refractory period, which is the sum of the rate-responsive AV delay and a programmable refractory period.

Claims

1. An implantable pacemaker, comprising:

atrial sensing means for sensing an intrinsic atrial rate in an atrial chamber of the heart;

pulse generating means for generating pacing pulses for delivery to the atrial and ventricular chambers of the heart;

defining means for defining a block entry rate and a block exit rate, the block entry and block exit rates being substantially equal; and

control means, coupled to the atrial sensing means, the pulse generating means, and to the defining means, for determining when the intrinsic atrial rate exceeds the block entry rate and when the intrinsic atrial rate falls below the block exit rate, and for pacing in the ventricle in a 2;

1 block response when the intrinsic atrial rate exceeds the block entry rate and for terminating the 2;

1 block response mode when the intrinsic atrial rate falls below the block exit rate.

2. The pacemaker of claim 1, further comprising:

means for defining a first threshold rate and a second threshold rate, wherein the pulse generating means generates pacing pulses for delivery to the ventricle at a rate not less than the first threshold rate and not greater than the second threshold rate.

3. The pacemaker of claim 2, further comprising:

means for defining a first atrial refractory period and a second atrial refractory period;

means for sensing at least one cardiac cycle;

means for defining a programmable total refractory period, comprising a sum of the first refractory period and the second refractory period, in each sensed cardiac cycle;

means for determining the intrinsic atrial rate by causing the atrial sensing means to sense all atrial events of each cardiac cycle, including atrial events occurring during the total refractory period of each cardiac cycle;

means for setting the second refractory period to a minimum value, corresponding to a minimum total refractory period, when the intrinsic atrial rate is greater than or equal to a second threshold rate; and

means for defining the block entry rate and the block exit rate as being inversely proportional to the minimum total refractory period.

4. The pacemaker of claim 2, further comprising:

means for defining a first atrial refractory period and a second atrial refractory period;

means for sensing at least one cardiac cycle;

means for defining a programmable total refractory period, comprising a sum of the first refractory period and the second refractory period, in each sensed cardiac cycle;

means for determining the intrinsic atrial rate by causing the atrial sensing means to sense all atrial events of each cardiac cycle, including atrial events occurring during the total refractory period of each cardiac cycle;

means for setting the second refractory period to a maximum value, corresponding to a maximum total refractory period, when the intrinsic atrial rate is less than or equal to the first threshold rate;

means for setting the second refractory period to a minimum value, corresponding to a minimum total refractory period, when the intrinsic atrial rate is greater than or equal to a second threshold rate;

means for setting the second refractory period to at least one intermediate value, corresponding to at least one intermediate total refractory period, when the intrinsic atrial rate is greater than the first threshold rate and less than the second threshold rate;

means for determining a sensed functional atrial rate by counting atrial events which occur outside of the total refractory period of each cardiac cycle; and

means for causing the pulse generating means to generate pacing pulses in the ventricular chamber at a ventricular pacing rate equal to the sensed functional atrial rate of each cardiac cycle.

5. The pacemaker of claim 4, wherein the control means comprises:

means for initiating a 2;

1 block response mode, at which the sensed functional atrial rate is one half of the intrinsic atrial rate, when at least one atrial event occurs during the minimum total refractory period; and

means for terminating the 2;

1 block response mode when no atrial events occur during the minimum total refractory period.

6. An implantable pacemaker, comprising:

atrial sensing means for sensing an intrinsic atrial rate in the atrial chamber of the heart;

pulse generating means for generating pacing pulses for delivery to the atrial and ventricular chambers;

defining means for defining a base rate and a maximum tracking rate (MTR); and

control means, coupled to the atrial sensing means, the pulse generating means, and to the defining means, for pacing the ventricular chamber so that the ventricular chamber is paced at a rate at least equal to the base rate, and at most equal to the MTR, the control means further comprising;

means for defining a programmable post ventricular atrial refractory period (PVARP);

means for defining a rate responsive AV delay (RRAVD);

means for sensing at least one cardiac cycle;

means for defining a programmable total atrial refractory period (TARP) comprising a sum of the PVARP and the RRAVD in each sensed cardiac cycle;

means for determining the intrinsic atrial rate by causing the atrial sensing means to sense all atrial events of each cardiac cycle, including atrial events occurring during the TARP of each cardiac cycle;

means for setting the RRAVD to a maximum value, corresponding to a maximum TARP, when the intrinsic atrial rate is less than or equal to the base rate;

means for setting the RRAVD to a minimum value, corresponding to a minimum TARP, when the intrinsic atrial rate is greater than or equal to a second threshold rate; and

means for setting the RRAVD to at least one intermediate value, corresponding to an intermediate TARP, when the intrinsic atrial rate is greater than the base rate and less than the second threshold rate.

7. The pacemaker of claim 6, further comprising defining means for defining a block entry rate at which a 2:

1 block response mode is initiated, the block entry rate being inversely proportional to the minimum TARP, and a block exit rate at which the 2;

1 block response mode is terminated, the block exit rate being inversely proportional to the minimum TARP.

8. The pacemaker of claim 6, wherein the control means comprises:

means for determining a sensed functional atrial rate by counting atrial events which occur outside of the TARP of each cardiac cycle; and

means for causing the pulse generating means to generate pacing pulses in the ventricular chamber at a ventricular pacing rate equal to the sensed functional atrial rate of each cardiac cycle.

9. The pacemaker of claim 8, wherein the control means comprises:

means for initiating a 2;

1 block response mode, during which the sensed functional atrial rate is one half of the intrinsic atrial rate, when at least one atrial event occurs during the minimum TARP; and

means for terminating the 2;

1 block response mode when no atrial events occur during the minimum TARP.

10. An implantable pacemaker, comprising:

means for defining a programmable total refractory period;

atrial sensing means for sensing an intrinsic atrial rate in an atrial chamber of a heart, the atrial sensing means comprising means for sensing atrial events during the total refractory period;

pulse generating means for generating pacing pulses for delivery to the atrial and ventricular chambers;

means for defining a block entry rate and a block exit rate, the block entry and block exit rates being substantially equal; and

first trigger means for initiating a 2;

1 block response when the intrinsic atrial rate exceeds the block entry rate; and

second trigger means for terminating a 2;

1 block response when the intrinsic atrial rate decreases below the block exit rate.

11. The pacemaker of claim 10, wherein the means for defining a programmable total refractory period includes means for defining first and second refractory periods which are programmable by the physician, and for defining the total refractory period as the sum of the first and the second refractory periods, the pacemaker further comprising:

means for defining a first threshold rate and a second threshold rate, wherein the pulse generating means generates pacing pulses for delivery to the ventricle at a rate at least equal to the first threshold rate, and at most equal to the second threshold rate;

monitoring means for determining when the intrinsic atrial rate is less than or equal to the first threshold rate, for determining when the intrinsic atrial rate is greater than or equal to the second threshold rate, and for determining when the intrinsic atrial rate is greater than the first threshold rate and less than the second threshold rate; and

selection means, responsive to the monitoring means, for automatically setting the second refractory period to a maximum value when the intrinsic atrial rate is less than or equal to a first threshold rate, for automatically setting the second refractory period to a minimum value when the intrinsic atrial rate is greater than or equal to a second threshold rate, and for automatically setting the second refractory period to at least one intermediate value when the intrinsic atrial rate is greater than the first threshold rate and less than the second threshold rate, whereby;

when the second refractory period is set to a minimum value, the total refractory period is equal to a minimum total refractory period;

when the second refractory period is set to at least one intermediate value, the total refractory period is equal to at least one intermediate total refractory period; and

when the second refractory period is set to a maximum value, the total refractory period is equal to a maximum total refractory period.

12. The pacemaker of claim 11 further comprising means for defining the block entry rate and the block exit rate as being inversely proportional to the minimum total refractory period.

13. The pacemaker of claim 11, further comprising:

means for determining a sensed functional atrial rate by counting atrial events which occur outside of the total refractory period of each cardiac cycle; and

third trigger means for causing the pulse generating means to generate pacing pulses in the ventricular chamber at a ventricular pacing rate equal to the sensed functional atrial rate of each cardiac cycle.

14. The pacemaker of claim 13, further comprising:

means for initiating a 2;

1 block response mode, at which the sensed functional atrial rate is one half of the intrinsic atrial rate, when at least one atrial event occurs during the minimum total refractory period; and

means for terminating a 2;

1 block response mode, at which the sensed functional atrial rate is one half of the intrinsic atrial rate, when no atrial events occur during the minimum total refractory period.

15. a method of operating an implantable pacemaker comprising the steps of:

coupling the pacemaker to, respectively, an atrial chamber and a ventricular chamber of a heart;

generating pacing pulses for delivery to the atrial and ventricular chambers of the heart;

defining a first refractory period and a second refractory period which are programmable by the physician;

defining a programmable total refractory period comprising a sum of the first refractory period and the second refractory period;

sensing an intrinsic atrial rate in an atrial chamber of the heart, including sensing of atrial events during the total refractory period;

defining a first threshold rate and a second threshold rate;

determining when the intrinsic atrial rate is less than or equal to the first threshold rate, when the intrinsic atrial rate is greater than or equal to the second threshold rate, and when the intrinsic atrial rate is greater than the first threshold rate and less than the second threshold rate; and

automatically selecting a maximum value for the second refractory period when the intrinsic atrial rate is less than or equal to a first threshold rate, automatically selecting a minimum value for the second refractory period when the intrinsic atrial rate is greater than or equal to a second threshold rate, and automatically selecting at least one intermediate value for the second refractory period when the intrinsic atrial rate is greater than the first threshold rate and less than the second threshold rate;

whereby the total refractory period equals a minimum total refractory period when the second refractory period is set to a minimum value, the total refractory period equals at least one intermediate total refractory period when the second refractory period is set to at least one intermediate value, and the total refractory period equals a maximum total refractory period when the second refractory period is set to a maximum value.

16. The method of claim 15, further comprising the steps of:

defining a block entry rate at which a 2;

1 block response mode is entered, as being inversely proportional to the minimum total refractory period; and

defining a block exit rate at which the 2;

1 block response mode is exited, as being inversely proportional to the minimum total refractory period, wherein the block entry and exit rates are substantially equal.

17. The method of claim 15, further comprising the steps of:

determining a sensed functional atrial rate by only counting atrial events which occur outside of the total refractory period of each cardiac cycle; and

generating pacing pulses in the ventricular chamber at a ventricular pacing rate equal to the sensed functional atrial rate of each cardiac cycle.

18. The method of claim 17, further comprising the steps of:

initiating a 2;

1 block response mode, at which the sensed functional atrial rate is one half of the intrinsic atrial rate, when at least one atrial event occurs during the minimum total refractory period; and

terminating a 2;

1 block response mode, at which the sensed functional atrial rate is one half of the intrinsic atrial rate, when no atrial events occur during the minimum total refractory period.