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Methods of MRI enhancement using compounds having improved functionalization

  • US 5,601,802 A
  • Filed: 06/07/1995
  • Issued: 02/11/1997
  • Est. Priority Date: 06/02/1995
  • Status: Expired due to Fees
First Claim
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1. A method of magnetic resonance image enhancement in a subject, the method comprising:

  • administering to the subject an effective amount of a texaphyrin; and

    imaging the subject using a magnetic resonance device;

    wherein the texaphyrin has structure;

    ##STR14## wherein M is a paramagnetic metal cation;

    R1 -R4, R7 and R8 are independently hydrogen, halide, hydroxyl, alkyl, aryl, haloalkyl, nitro, formyl, acyl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, saccharide, carboxy, carboxyalkyl, carboxyamidealkyl, a site-directing molecule,a catalytic group, or a couple to a site-directing molecule or to a catalytic group;

    R6 and R9 are independently selected from the groups of R1 -R4, R7 and R8, with the proviso that the halide is other than iodide and the haloalkyl is other than iodoalkyl;

    R5 and R10 -R12 are independently hydrogen, alkyl, aryl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, carboxyalkyl, carboxyamidealkyl or a couple to a saccharide, to a site-directing molecule or to a catalytic group;

    at least one of R5, R6, R9, R10, R11 and R12 is other than hydrogen; and

    Z is an integer less than or equal to 5.

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