Thermophilic fungal expression system
First Claim
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1. A recombinant Thielavia strain comprising a nucleic acid sequence encoding a heterologous protein.
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Abstract
The present invention relates to recombinant thermophilic host cells comprising a nucleic acid sequence encoding a heterologous protein, and a method of producing recombinant protein utilizing same. The recombinant hosts of the present invention provide a better morphology in tank fermentations than many known fungal host cells, such as Aspergillus, which morphology results in lower viscosity levels, and therefore improved productivity.
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19 Claims
- 1. A recombinant Thielavia strain comprising a nucleic acid sequence encoding a heterologous protein.
- 10. A method for producing a protein of interest which comprises culturing a recombinant Thielavia strain comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter, under conditions which permit expression of the protein, and recovering the protein from culture.
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