Method to enhance the immune system of a human
First Claim
1. A method of improving the immune response sensitivity of the the immune system of a human infant, wherein said method comprises feeding a human infant in need of treatment a formula, the improvement comprising feeding said human infant a formula consisting essentially of:
- 1) protein, said protein being of a concentration of between 10 and 35 grams per liter of formula;
2) fat, said fat being of a concentration of between 20 and 45 grams per liter of formula;
3) carbohydrates, said carbohydrates being of a concentration of between 60 and 110 grams per liter of formula; and
4) at least 70 mg of nucleotide equivalents per liter of formula, said nucleotide equivalents are nucleotide equivalents of each of adenosine, cytidine, guanosine and uridine, and wherein the concentration of said cytidine nucleotide equivalents are in the range of from 29 to 39 mg/liter of said formula, the concentration of said uridine nucleotide equivalents are in the range of from 15 to 20 mg/liter of said formula, the concentration of said adenosine nucleotide equivalents are in the range of from 10 to 15 mg/liter of said formula, and the concentration of said guanosine nucleotide equivalents are in the range of from 14 to 20 mg/liter of said formula.
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Abstract
An improved enteral nutritional formula containing ribo-nucleotide equivalents (RNA, mono-, di- and triphosphate nucleotides, nucleosides and adjuncts such as activated sugars) at a level of at least 10 mg/100 Kcal (kilocalorie) of formula is disclosed. The formula comprises carbohydrates, lipids, proteins, vitamins and minerals and four (4) ribo-nucleotide equivalents at specific levels and ratios. The invention also discloses novel methods of production and analytical techniques. This invention also provides a dietary formula that enhances the immune system and alleviates diarrhea.
80 Citations
24 Claims
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1. A method of improving the immune response sensitivity of the the immune system of a human infant, wherein said method comprises feeding a human infant in need of treatment a formula, the improvement comprising feeding said human infant a formula consisting essentially of:
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1) protein, said protein being of a concentration of between 10 and 35 grams per liter of formula; 2) fat, said fat being of a concentration of between 20 and 45 grams per liter of formula; 3) carbohydrates, said carbohydrates being of a concentration of between 60 and 110 grams per liter of formula; and 4) at least 70 mg of nucleotide equivalents per liter of formula, said nucleotide equivalents are nucleotide equivalents of each of adenosine, cytidine, guanosine and uridine, and wherein the concentration of said cytidine nucleotide equivalents are in the range of from 29 to 39 mg/liter of said formula, the concentration of said uridine nucleotide equivalents are in the range of from 15 to 20 mg/liter of said formula, the concentration of said adenosine nucleotide equivalents are in the range of from 10 to 15 mg/liter of said formula, and the concentration of said guanosine nucleotide equivalents are in the range of from 14 to 20 mg/liter of said formula. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9)
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6. A method as claimed in claim I wherein said protein is of a concentration of 13 to 15 grams per liter of formula, said fat is of a concentration of 30 to 40 grams per liter of formula and has as its source a blend of soy oils, coconut oils and high oleic safflower oil, and said carbohydrates are of a concentration of 70 to 80 grams per liter of formula, and dietary fiber, said dietary fiber is soy polysaccharide derived from soy beans.
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10. A method of improving the immune response sensitivity of the immune system of a human infant, said method comprising feeding a human infant in need of treatment a nutritional formula, the improvement comprising a human infant a nutritionally complete formula comprising:
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1) protein; 2) fat; 3) carbohydrates; 4) at least 70 mg of nucleotides per liter of formula, said nucleotides comprising the monophosphate esters of adenosine, cytidine, guanosine and uridine and wherein the weight ratio of CMP;
UMP is at least 1.5;
1;
of CMP;
AMP is at least 2;
1 and of CMP;
GMP is at least 1.75;
1; and
wherein the concentration of said cytidine monophosphate esters are in the range of from 29 to 39 mg/liter of said formula, the concentration of said uridine monophosphate esters are in the range of from 15 to 20 mg/liter of said formula, the concentration of said adenosine monophosphate esters are in the range of from 10 to 15 mg/liter of said formula, and the concentration of said guanosine monophosphate esters are in the range of from 14 to 20 mg/liter of said formula. - View Dependent Claims (11, 12, 13)
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14. A method of improving the immune response sensitivity of the immune system of a human infant to an antigen, said method comprising feeding a human infant in need of treatment a nutritional formula, the improvement comprising feeding said human infant an infant formula that contains 29-39 mg of CMP per liter of formula;
- 15-21 mg of UMP per liter of formula;
10-16 mg of AMP per liter or formula and 14-20 mg of GMP per liter of formula or their nucleotide equivalents and wherein the weight ratio of CMP;
UMP is at least 1.5;
1;
of CMP;
AMP is at least 2;
1; and
of CMP;
GMP is at least 1.75;
1. - View Dependent Claims (15)
- 15-21 mg of UMP per liter of formula;
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16. A method for the treatment and prevention of diarrheal disease in human infants which comprises administering to a human infant in need of such treatment an infant formula which comprises a therapeutically effective amount of a source of amino nitrogen, carbohydrates, edible fats, minerals, vitamins and a composition comprising at least one member selected from each of the groups (a), (b), (c), and (d):
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(a) uridine, uridine phosphates and mixtures thereof; (b) guanosine, guanosine phosphates and mixtures thereof; (c) adenosine, adenosine phosphates and mixtures thereof; (d) cytidine, cytidine phosphates and mixtures thereof; wherein the total amount of the composition is at least 70 mg per liter of formula, wherein the concentration of component (a) is in the range of 30-33 mg/liter, the concentration of component (b) is in the range of 16-19 mg/liter, the concentration of component (c) is in the range of 11-14 mg/liter, the concentration of component (d) is in the range of 15-18 mg/liter.
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17. A method for the treatment of diarrheal disease in a human infant, wherein said method comprises feeding a human infant in need of treatment a formula, the improvement comprising feeding said human infant a formula consisting essentially of:
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1) protein, said protein being of a concentration of between 10 and 35 grams per liter of formula; 2) fat, said fat being of a concentration of between 20 and 45 grams per liter of formula; 3) carbohydrates, said carbohydrates being of a concentration of between 60 and 110 grams per liter of formula; and 4) at least 70 mg of nucleotide equivalents per liter of formula, said nucleotide equivalents are nucleotide equivalents of each of adenosine, cytidine, guanosine and uridine and wherein the concentration of said cytidine nucleotide equivalents are in the range of from 29 to 39 mg/liter of said formula, the concentration of said uridine nucelotide equivalents are in the range of from 15 to 20 mg/liter of said formula, the concentration of said adenosine nucelotide equivalents are in the range of from 10 to 15 mg/liter of said formula, and the concentration of said guanosine nucleotide equivalents are in the range of from 14 to 20 mg/liter of said formula. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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Specification