Method for coating catheter lumens

• US 5,603,991 A
• Filed: 09/29/1995
• Issued: 02/18/1997
• Est. Priority Date: 09/29/1995
• Status: Expired due to Term

• Current Assignee: Target Therapeutics, Inc. (Boston Scientific Corporation)
• Original Assignee: Target Therapeutics, Inc. (Boston Scientific Corporation)
• Inventors: Kupiecki, David, Han, Thuzar K.
• Primary Examiner(s): PIANALTO, BERNARD D
• Application Number:
  US08/539,902
• Time in Patent Office: 508 Days
• Field of Search: 427/508, 427/512, 427/558, 427/559, 427/581, 427/230, 427/393.5, 427/430.1
• US Class Current: 427/508
• CPC Class Codes: A61M 2025/0047 the inner layer having a higher lubricity
• CPC Class Codes: A61M 25/0009 Making of catheters or other medical or surgical tubes
• CPC Class Codes: A61M 25/0045 multi-layered, e.g. coated coating materials A61L29/08

Abstract

This invention is in the general field of surgical instruments and, in particular, catheters. Specifically, it relates to procedures for coating the interior surfaces of surgical devices with a cross-linkable lubricious polymer, preferably one which is hydrophilic. These catheters may be variously used in cardiovascular and endovascular procedures to deliver diagnostic, therapeutic, or vaso-occlusive agents or devices to a target site within a human or animal body and to catheters used to guide other catheters to a particular site in that body. The interior of the catheters are coated using the noted procedure in such a way that the interior is exceptionally slippery and very durable.

Claims

1. A method for producing a thin coating of a covalently bonded polymer coating on the interior of an elongated tubular member, which process comprises the steps of:

a.) supplying an elongated tubular member having an outer surface and an inner lumen which elongated tubular member is composed of a polymeric material sufficiently uv-transparent to allow cross-linking of a uv-cross-linkable polymer or oligomer on said inner lumen,

b.) applying a dilute solution or suspension of a solvent and a uv-cross-linkable polymer or oligomer to the inner lumen of said elongated tubular member to form a sheet comprising said solvent and polymer or oligomer,

c.) removing at least a substantial portion of the solvent from the sheet, and

d.) curing said polymer or oligomer by ultraviolet radiation passing from the outer surface of said elongated tubular member to said inner lumen so to covalently bond said polymer to the lumen of said elongated tubular member.

2. The method of claim 1 additionally comprising the steps of sequentially repeating steps a.) and b.) and c.) and d.).

3. The method of claim 1 where the dilute solution or suspension comprises a solvent selected from ethers, alcohols, water, and mixtures.

4. The method of claim 3 where the solvent is selected from methanol, ethanol, isopropanol, water, and mixtures.

5. The method of claim 3 where the solution or suspension contains 0.25% to 5.0% (wt) of polymer precursor.

6. The method of claim 5 where the solution or suspension contains 0.25% to 2.5% (wt) of polymer precursor.

7. The method of claim 1 where the dilute monomer or oligomer solution contains polymers or oligomers of monomers selected from ethylene oxide;

2-vinyl pyridine;

N-vinyl pyrrolidone;

polyethylene glycol acrylates including monoalkoxypolyethyleneglycolmono(meth) acrylate, monomethoxytriethyleneglycolmono(meth) acrylate, monomethoxytetraethyleneglycolmono(meth) acrylate, polyethyleneglycolmono(meth) acrylate;

hydrophilic acrylates such as 2-hydroxyethylmethylacrylate, glycerylmethylacrylate, acrylic acid and its salts;

acrylamide and acrylonitrile;

acrlylamidomethylpropane sulfonic acid and its salts;

cellulose, cellulose derivatives, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, cyanoethyl cellulose, cellulose acetate, polysaccharides such as amylose, pectin, amylopectin, alginic acid, and cross-linked heparin.

8. The method of claim 1 where the temperature of the solvent removal step is between 25°

C. and the glass transition temperature of the polymer of the elongate tubular member.

9. The method of claim 8 where the temperature of the solvent removal step is between 50°

C. and 125°

C.

10. The method of claim 1 where the curing step comprises the application of ultraviolet light at a radiation density of 10 to 1200 mW/cm² to the polymeric substrate.

11. The method of claim 10 where the curing step comprises the application of ultraviolet light at a radiation density of 10 to 250 mW/cm² at a 300-350 nm wavelength to the polymeric substrate.