Releasable multiwell plate cover
First Claim
1. A pad for use in sealing wells having openings in the upper surface of a multi-well plate, comprisinga flexible polymer sheet defining a planar expanse adapted to cover the wells in the plate, andformed on said expanse, a plurality of resiliently compressible ridges adapted to seat over the openings of said wells, with the pad placed operatively over the plate,said ridges being deformable, with application of a substantially uniform pressure applied to the side of the sheet opposite said expanse, to form a substantially fluid-tight seal between said expanse and such well openings, andsaid ridges extending from said expanse sufficiently to break said seal upon release of said pressure.
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Accused Products
Abstract
A cover effective to releasably seal a multiwell container, such as a microtitration plate, is disclosed. The cover contains a pad, fashioned from a flexible polymer sheet, and a plurality of resiliently compressible ridges formed on the sheet. The ridges are deformable, such that application of pressure applied to the cover is effective to form a fluid-tight seal between the pad and the well openings. The ridges extend from the pad sufficiently to break the seal upon release of the pressure.
237 Citations
21 Claims
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1. A pad for use in sealing wells having openings in the upper surface of a multi-well plate, comprising
a flexible polymer sheet defining a planar expanse adapted to cover the wells in the plate, and formed on said expanse, a plurality of resiliently compressible ridges adapted to seat over the openings of said wells, with the pad placed operatively over the plate, said ridges being deformable, with application of a substantially uniform pressure applied to the side of the sheet opposite said expanse, to form a substantially fluid-tight seal between said expanse and such well openings, and said ridges extending from said expanse sufficiently to break said seal upon release of said pressure.
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11. In an automated plate handling apparatus of the type having a tray for receiving a multiwell plate having a plurality of wells with upper planar openings, sample-handling means for heating or shaking the wells, and a sealing assembly including a cover and means for moving said cover from a retracted position toward a sealing position, a pad attached to said cover for use in sealing the wells of said plate, with the cover moved toward its sealing position, at which the pad is pressed against the surface of the plate, where in the improvement comprises, said pad comprising
a flexible polymer sheet defining a planar expanse dimensioned to cover the wells in the plate, and formed on said expanse, a plurality of resiliently compressible ridges adapted to seat over the openings of said wells, said ridges being deformable, as the cover is moved toward its sealing position, to form a substantially fluid-tight seal between said expanse and such well openings, said ridges extending from said expanse sufficiently to break said seal upon movement of the cover toward its retracted position.
Specification