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Pharmaceutical compositions for prevention and treatment of ulcerative colitis

  • US 5,604,231 A
  • Filed: 01/06/1995
  • Issued: 02/18/1997
  • Est. Priority Date: 01/06/1995
  • Status: Expired due to Fees
First Claim
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1. A method for providing prevention or treatment of an inflammatory bowel disease, the method comprising administering to a subject an effective amount of a compound having the formula:

  • ##STR3## where X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75;

    n is an integer which ranges from 1 to 5;

    Z'"'"' and Z" individually represent hydrogen or alkyl containing one to five carbon atoms;

    A, A'"'"' and A" individually represent hydrogen, alkyl containing one to seven carbon atoms, or halo;

    the dashed line in the structure represents a C--C single bond, a C--C double bond or a C--C triple bond;

    the wavy line in the structure represents a cis (Z) or trans (E) form of the compound when the dashed line is a C--C double bond; and

    X'"'"' represents CH2 when the dashed line is a C--C single bond, CH when the dashed line is a C--C double bond, and C when the dashed line is a C--C triple bond.

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