Pharmaceutical compositions for prevention and treatment of ulcerative colitis
First Claim
1. A method for providing prevention or treatment of an inflammatory bowel disease, the method comprising administering to a subject an effective amount of a compound having the formula:
- ##STR3## where X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75;
n is an integer which ranges from 1 to 5;
Z'"'"' and Z" individually represent hydrogen or alkyl containing one to five carbon atoms;
A, A'"'"' and A" individually represent hydrogen, alkyl containing one to seven carbon atoms, or halo;
the dashed line in the structure represents a C--C single bond, a C--C double bond or a C--C triple bond;
the wavy line in the structure represents a cis (Z) or trans (E) form of the compound when the dashed line is a C--C double bond; and
X'"'"' represents CH2 when the dashed line is a C--C single bond, CH when the dashed line is a C--C double bond, and C when the dashed line is a C--C triple bond.
2 Assignments
0 Petitions
Accused Products
Abstract
Patients suffering from or susceptible to an idiopathic chronic inflammatory bowel disease (e.g., ulcerative colitis) are treated with pharmaceutical compositions. Those patients are treated by administration of an effective amount of aryl substituted aliphatic compound, an aryl substituted olefinic amine compound or an aryl substituted acetylenic compound. Exemplary compounds are (E)-4-(5-pyrimidinyl)-3-butene-1-amine, (E)-4-[3-(5-methoxypyridin)yl]-3-butene-1-amine, (E)-N-methyl-4-(5-pyrimidinyl)-3-butene-1-amine, (E)-N-methyl-4-[3-(5-methoxypyridin)yl]-3-butene-1-amine, (E)-metanicotine, (Z)-metanicotine, N-methyl-(3-pyridinyl)-butane-1-amine, N-methyl-4-(3-pyridinyl)-3-butyne-1-amine and (E)-N-methyl-4 -[3-(6-methylpyrindin)yl]-3-butone-1-amine.
245 Citations
21 Claims
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1. A method for providing prevention or treatment of an inflammatory bowel disease, the method comprising administering to a subject an effective amount of a compound having the formula:
- ##STR3## where X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75;
n is an integer which ranges from 1 to 5;
Z'"'"' and Z" individually represent hydrogen or alkyl containing one to five carbon atoms;
A, A'"'"' and A" individually represent hydrogen, alkyl containing one to seven carbon atoms, or halo;
the dashed line in the structure represents a C--C single bond, a C--C double bond or a C--C triple bond;
the wavy line in the structure represents a cis (Z) or trans (E) form of the compound when the dashed line is a C--C double bond; and
X'"'"' represents CH2 when the dashed line is a C--C single bond, CH when the dashed line is a C--C double bond, and C when the dashed line is a C--C triple bond. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- ##STR3## where X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75;
Specification