System and method for determining spatial organization of atrial activation

• US 5,605,159 A
• Filed: 02/16/1996
• Issued: 02/25/1997
• Est. Priority Date: 02/16/1996
• Status: Expired due to Term

• Current Assignee: Gregory W. Botteron, Joseph M. Smith
• Original Assignee: Gregory W. Botteron, Joseph M. Smith
• Inventors: Smith, Joseph M., Botteron, Gregory W.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/602,957
• Time in Patent Office: 375 Days
• Field of Search: 128/642, 128/702, 128/705, 128/696, 128/695 R, 128/697, 364/413.06
• US Class Current: 600/515
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/308 for electrocardiography [ECG]
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

A system and method evaluates the spatial organization of atrial activation sequences of a heart. Electrical activity of an atrium is sensed at a predetermined number of different localized locations within the atrium to generate a like predetermined number of electrograms. The electrogram generated for each localized location is cross-correlated with the electrograms generated for every other localized location to derive a set of correlation values. A space constant derivable from the correlation values or the correlation values themselves may be used to evaluate antiarrhythmic drug effectiveness or, within an implantable atrial defibrillator, atrial arrhythmia type.

Claims

1. A method of evaluating the effectiveness of a medication towards terminating an atrial arrhythmia of a heart of a patient, said method including the steps of:

(a) sensing electrical activity of an atrium of a heart at a predetermined number of different localized locations within the atrium, the localized locations being spaced apart by preselected distances with respect to each other;

(b) generating a like predetermined number of electrograms, each electrogram representing the electrical activity sensed at each of the predetermined number of localized locations;

(c) cross-correlating the electrogram generated for at least one of the localized locations with the electrogram generated for at least one other one of the localized locations to derive a pre-medication correlation value for at least one of the preselected distances;

(d) administering the medication to the patient;

(e) after a predetermined period of time, repeating steps (a) and (b);

(f) cross-correlating the electrogram generated for said at least one of the localized locations with the electrogram generated for said at least one other of the localized locations to derive a post-medication correlation value for said at least one of the preselected distances;

(g) comparing the pre-medication correlation value to the post-medication correlation value, and

(h) determining if post-medication correlation value is greater than the pre-medication correlation value.

2. A method of evaluating the effectiveness of a medication upon an atrial arrhythmia of a heart of a patient, said method including the steps of:

(a) sensing electrical activity of an atrium of a heart at a predetermined number of different localized locations within the atrium, the localized locations being spaced apart by preselected distances with respect to each other;

(b) generating a like predetermined number of electrograms, each electrogram representing the electrical activity sensed at each of the predetermined number of localized locations;

(c) cross-correlating the electrogram generated for each localized location with the electrogram generated for every other localized location to derive a pre-medication correlation value for each preselected distance;

(d) administering the medication to the patient;

(e) after a predetermined period of time, repeating steps (a) and (b);

(f) cross-correlating the electrogram generated for each localized location with the electrogram generated for every other localized location to derive a post-medication correlation value for each preselected distance;

(g) deriving a pre-medication average correlation value from the pre-medication correlation values for each preselected distance;

(h) deriving a pre-medication space constant from the pre-medication average correlation values;

(i) deriving a post-medication average correlation value from the post-medication correlation value for each preselected distance;

(j) deriving a post-medication space constant from the post-medication average correlation values;

(k) comparing the pre-medication space constant to the post-medication space constant; and

(l) determining if the post-medication space constant is greater then the pre-medication space constant.