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System and method for determining spatial organization of atrial activation

  • US 5,605,159 A
  • Filed: 02/16/1996
  • Issued: 02/25/1997
  • Est. Priority Date: 02/16/1996
  • Status: Expired due to Term
First Claim
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1. A method of evaluating the effectiveness of a medication towards terminating an atrial arrhythmia of a heart of a patient, said method including the steps of:

  • (a) sensing electrical activity of an atrium of a heart at a predetermined number of different localized locations within the atrium, the localized locations being spaced apart by preselected distances with respect to each other;

    (b) generating a like predetermined number of electrograms, each electrogram representing the electrical activity sensed at each of the predetermined number of localized locations;

    (c) cross-correlating the electrogram generated for at least one of the localized locations with the electrogram generated for at least one other one of the localized locations to derive a pre-medication correlation value for at least one of the preselected distances;

    (d) administering the medication to the patient;

    (e) after a predetermined period of time, repeating steps (a) and (b);

    (f) cross-correlating the electrogram generated for said at least one of the localized locations with the electrogram generated for said at least one other of the localized locations to derive a post-medication correlation value for said at least one of the preselected distances;

    (g) comparing the pre-medication correlation value to the post-medication correlation value, and(h) determining if post-medication correlation value is greater than the pre-medication correlation value.

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