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Reversible charge-based sequestration on solid support

  • US 5,605,616 A
  • Filed: 11/06/1995
  • Issued: 02/25/1997
  • Est. Priority Date: 11/06/1995
  • Status: Expired due to Fees
First Claim
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1. A method for modifying a substrate compound, the method comprising:

  • (i) providing, in a reaction mixture, a substrate compound comprising a reactive moiety;

    (ii) contacting the reactive moiety with a reactant to form a modified substrate compound;

    (iii) providing a solid support, wherein one of said substrate compound and said solid support comprises a selectively chargeable moiety (SCM) having a non-associating charge state;

    (iv) altering the non-associating charge state of the selectively chargeable moiety to an associating charge state;

    (v) contacting the modified substrate compound with the solid support such that the modified substrate compound is sequestered by the solid support; and

    (vi) altering the associating charge state of the selectively chargeable moiety to a non-associating charge state such that the modified substrate compound is not sequestered by the solid support.

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