Dialysis probe

• US 5,607,390 A
• Filed: 06/20/1995
• Issued: 03/04/1997
• Est. Priority Date: 12/15/1992
• Status: Expired due to Term

• Current Assignee: Institute of Neurology
• Original Assignee: Institute of Neurology
• Inventors: O'Connell, Mark L., Patsalos, Philip N.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US08/446,866
• Time in Patent Office: 623 Days
• Field of Search: 604/27, 604/28, 604/29, 604/43, 604/280-284, 604/246, 604/264, 604/174, 128/769, 128/768, 128/760, 128/632
• US Class Current: 604/29
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61M 25/02 Holding devices, e.g. on the body

Abstract

A dialysis probe for insertion into the human or animal body includes a tubular dialysis membrane (2) closed at its distal end (3); an inlet tube (4) for supplying perfusion fluid into the body of the dialysis membrane (2); and an outlet tube (5) for the exit of perfusion fluid from the body of the dialysis membrane, the inlet and outlet tubes being provided at the proximal end of the tubular dialysis membrane (2) and making sealed connection with the interior of the dialysis membrane. An anchoring member (7, 20) is provided at the proximal end of the probe and in a first embodiment comprises a plate-like member for securing directly to the body of the subject, and in a second embodiment comprises a stopper cap (21, 22, 23, 24) for plugging a cannula itself attached to the body of the subject. The anchoring member has all the remaining component parts of the probe bounded, directly or indirectly, to it.

Claims

1. A dialysis probe for insertion into a human or animal body, the probe comprising:

a tubular dialysis membrane closed at a distal end;

an inlet tube for supplying perfusion fluid into a body of the dialysis membrane;

an outlet tube for the exit of perfusion fluid from the body of the dialysis membrane;

the inlet and outlet tubes

being provided at a proximal end, of the tubular dialysis membrane and making a sealed connection with an interior of the dialysis membrane;

an anchoring member is provided at the proximal end of the dialysis membrane;

each of the dialysis membrane, the inlet tube and the outlet tube is bonded to the anchoring member; and

the anchoring member includes attachment means for securing it to an outside of the human or animal body.

2. A probe as claimed in claim 1, wherein the attachment means is arranged to be secured indirectly to the body of the subject and comprises a stopper surrounding the dialysis membrane for plugging a lumen of a cannula secured to the outside of the body of the subject.

3. A probe as claimed in claim 2, wherein the stopper is a cap comprising a central plug portion to enter the interior of the cannula, an annular head portion extending transversely to the axis of the probe, and an annular wall projecting from the annular head portion towards the distal end of the probe to engage the exterior of the cannula.

4. A probe as claimed in claim 3, wherein the interior of the annular wall is provided with a screw thread.

5. A probe as claimed in claim 2, wherein the dialysis membrane projects beyond the attachment means at the proximal end of the probe.

6. A probe as claimed in claim 1, wherein the attachment means is arranged to be secured directly to the body of the subject and each of the dialysis membrane, the inlet tube and the outlet tube is bonded directly to the anchoring member.

7. A probe as claimed in claim 6, wherein one end of a respective flexible connecting tube is connected to the proximal end of each of the inlet and outlet tubes, and the one said of each connecting tube is bonded to the anchoring member.

8. A probe as claimed in claim 1, wherein an impermeable sheath is provided on the interior of the exterior of the tubular dialysis membrane and extends from the proximal end of the probe to a position part way along the length of the dialysis membrane, in particular, the sheath extending to within 5, or within 2, or within 1 centimeters of the distal end of the dialysis membrane.

9. A probe as claimed in claim 8, wherein the sheath comprises an impermeable coating on the outside of the dialysis membrane, or a sleeve mounted on the dialysis membrane and bonded to the anchoring member.

10. A probe as claimed in claim 8, wherein the dialysis membrane and the sheath are both flexible.

11. A probe as claimed in claim 1, wherein the outlet tube extends within the dialysis membrane from the proximal end of the probe to a point close to the distal end of the dialysis membrane, in particular, within 5, or within 2, or within 1 centimeters of the distal end of the dialysis membrane.

12. A probe as claimed in claim 8, wherein the sheath extends to point close to but before the distal end of the outlet tube.

13. A probe as claimed in claim 1, wherein the inlet tube enters the proximal end of the dialysis membrane, in particular, extending within the dialysis membrane by more than half of the dialysis membrane.

14. A probe as claimed in claim 6, wherein the anchoring member comprises a resilient flexible plate-like member defining first and second wings extending on opposite sides of the longitudinal axis of the tubular dialysis membrane, the flexibility of the plate-like member permitting the wings to be bent together for gripping between the finger and thumb for deployment of the probe.

15. A probe as claimed in claim 14, wherein each wing includes a respective aperture to permit suturing the probe to the subject.

16. A probe as claim in claim 15, wherein the plate-like member is moulded about the dialysis membrane, the inlet and outlet tubes and, where provided, the sheath.

17. A probe as claimed in claim 15, wherein the plate-like member is formed of two parts, one part overlying the other, and the dialysis membrane, the inlet and outlet tubes and, where provided, the sheath are located between the two parts.

18. A probe as claimed in claim 1, wherein the diameter of the dialysis membrane is in the range 1 to 10, or 1 to 5, or 0.2 to 1.0, or 0.2 to 0.5, or 0.1 to 0.2, or 0.5 to 0.1 millimeters inclusive.

19. A probe as claimed in claim 1, wherein the distal end of the dialysis membrane is closed by the material of the membrane itself.