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Biocompatible medical article and method

  • US 5,607,475 A
  • Filed: 08/22/1995
  • Issued: 03/04/1997
  • Est. Priority Date: 08/22/1995
  • Status: Expired due to Fees
First Claim
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1. An endoprosthesis having a metal surface contacting body fluids, the metal surface having a coating thereon comprising:

  • (a) a silane which includes a vinyl functionality, the silane adherent to the metal surface such that the vinyl functionality is pendant from the surface;

    (b) a graft polymer, the graft polymer covalently bonded with the pendant vinyl functionality of the adherent silane, the graft polymer simultaneously formed and bonded to the pendant vinyl functionality by free radical reaction initiated by an oxidizing metal with at least one ethylenically unsaturated monomer selected from the group consisting of acrylamide and acrylic acid;

    (c) a polyamine spacer covalently attached to the graft polymer; and

    (d) a biomolecule covalently attached to the spacer.

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