Biocompatible medical article and method
First Claim
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1. An endoprosthesis having a metal surface contacting body fluids, the metal surface having a coating thereon comprising:
- (a) a silane which includes a vinyl functionality, the silane adherent to the metal surface such that the vinyl functionality is pendant from the surface;
(b) a graft polymer, the graft polymer covalently bonded with the pendant vinyl functionality of the adherent silane, the graft polymer simultaneously formed and bonded to the pendant vinyl functionality by free radical reaction initiated by an oxidizing metal with at least one ethylenically unsaturated monomer selected from the group consisting of acrylamide and acrylic acid;
(c) a polyamine spacer covalently attached to the graft polymer; and
(d) a biomolecule covalently attached to the spacer.
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Abstract
A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface an silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.
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Citations
12 Claims
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1. An endoprosthesis having a metal surface contacting body fluids, the metal surface having a coating thereon comprising:
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(a) a silane which includes a vinyl functionality, the silane adherent to the metal surface such that the vinyl functionality is pendant from the surface; (b) a graft polymer, the graft polymer covalently bonded with the pendant vinyl functionality of the adherent silane, the graft polymer simultaneously formed and bonded to the pendant vinyl functionality by free radical reaction initiated by an oxidizing metal with at least one ethylenically unsaturated monomer selected from the group consisting of acrylamide and acrylic acid; (c) a polyamine spacer covalently attached to the graft polymer; and (d) a biomolecule covalently attached to the spacer. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An endoprosthesis having a metal surface contacting body fluids, the metal surface having a coating thereon comprising:
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(a) a silane having the structure
space="preserve" listing-type="equation">C.sub.2 H.sub.3 --R--Si--X.sub.3,wherein X is a halogen, methoxy or ethoxy group and R is an optional short chain alkyl group, the silane adherent to the metal surface such that the vinyl functional group is pendant from the surface; (b) a graft polymer, the graft polymer covalently bonded with the pendant vinyl functionality of the adherent silane, the graft polymer simultaneously formed and bonded to the pendant vinyl functionality by free radical reaction initiated by an oxidizing metal with at least one ethylenically unsaturated monomer selected from the group consisting of acrylamide and acrylic acid; and (c) a biomolecule covalently attached to the graft polymer. - View Dependent Claims (8, 9, 10, 11, 12)
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Specification