Antimicrobial compositions useful for medical applications

• US 5,607,683 A
• Filed: 06/07/1995
• Issued: 03/04/1997
• Est. Priority Date: 04/10/1991
• Status: Expired due to Fees

• Current Assignee: Christopher C. Capelli
• Original Assignee: Christopher C. Capelli
• Inventors: Capelli, Christopher C.
• Primary Examiner(s): Hulina, Amy
• Application Number:
  US08/483,815
• Time in Patent Office: 636 Days
• Field of Search: 424/404, 424/405, 424/422, 424/423, 424/430, 424/432, 424/443, 424/486, 424/618, 424/609, 424/669, 424/663, 424/722, 424/723, 424/678, 424/679, 424/680, 424/670, 514/495, 604/265, 523/105, 523/113, 523/122, 523/111
• US Class Current: 424/405
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/16 Foams
• CPC Class Codes: A01N 25/22 containing ingredients stabilising the active ingredients
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A46D 1/00 Bristles; Selection of materials for bristles making artificial bristles D01D, D01F
• CPC Class Codes: A46D 1/006 Antimicrobial, disinfectant bristles, handle, bristle-carrier or packaging
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61K 47/6949 inclusion complexes, e.g. clathrates, cavitates or fullerenes
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Antimicrobial metal-based compositions, which are photostable, non-staining, and which are easily absorbed into lipophilic matrices, contain silver cations, complexed by acyclic polyether polymers through the formation of a "host-guest relationship" where the acyclic polyether is the "host" and the silver cation is the "guest," wherein stabilization of this "host-guest relationship" is accomplished through the use of excess anions. The compositions are useful for topical treatment of infections caused by bacteria, fungus and viruses in humans and animals and for treating medical devices, foams and adhesives to impart infection-resistance.

Claims

1. An antimicrobial composition consisting essentially of

(a) a stabilizing acyclic polyether polymer;

(b) silver ion; and

(c) a stabilizing anion, selected from the group consisting of chloride, bromide, iodide and thiocyanate, wherein the ratio of equivalents of said anion to equivalents of said silver ion is greater than 4 to 1, when said anion is chloride;

is greater than 2.1 to 1, when said anion is bromide; and

is greater than 1.1 to 1, when said anion is iodide;

is greater than 3.5 to 1 when said anion is thiocyanate; and

wherein said acyclic polyether polymer is selected from the group consisting of polyethylene glycol block copolymers and polyethyleneglycol mono (nonylphenyl) ether; and

wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight.

6. The composition of claim 1, wherein said silver cation is present in the composition in an amount ranging from 1×

10^-6 to 1 meq of silver ion per gram of acyclic polyether polymer.

7. The composition of claim 6, wherein said amount of silver ion is in the range of from 1×

10^-3 to 1×

10^-1 meq of silver ion per gram of acyclic polyether polymer.

8. The composition of claim 1, wherein said acyclic polyether polymer is a polyethylene glycol block copolymer.

9. The composition of claim 8, wherein said polyethylene glycol block copolymer is a poloxamer.

10. The composition of claim 1, wherein said acyclic polyether polymer is polyethyleneglycol mono (nonylphenyl) ether.

11. The composition of claim 1, wherein the ratio of chloride to silver ion is from 9:

1 to 100;

1.

12. A method of treating infection in a mammal, comprising the step of applying to an infected site of said mammal a disinfecting amount of the antimicrobial composition of claim 1.

13. A method of imparting antimicrobial protection to an object, comprising the step of applying to said object an effective protecting amount of an antimicrobial composition of claim 1.

14. The method of claim 13, wherein said object is a medical device selected from the group consisting of a medical implant, a wound care device, a personal protection device, a body cavity device and a birth control device.

15. The composition of claim 1, wherein the ratio of equivalents of said anion to equivalents of said silver ion is greater than 10 to 1, when said anion is chloride;

is greater than 3 to 1, when said anion is bromide;

is greater than 1.2 to 1, when said anion is iodide; and

is greater than 4 to 1 when said anion is thiocyanate; and

wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight.

16. The composition of claim 1, wherein the ratio of equivalents of said anion to equivalents of said silver ion is greater than 15 to 1, when said anion is chloride;

is greater than 3.5 to 1, when said anion is bromide;

is greater than 1.4 to 1, when said anion is iodide;

is greater than 5 to 1 when said anion is thiocyanate; and

wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight.

2. An antimicrobial composition consisting essentially of

(a) a stabilizing acyclic polyether polymer;

(b) silver ion; and

(c) thiocyanate, wherein the ratio of equivalents of said thiocyanate to equivalents of said silver ion is greater than 3.5 to 1; and

wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight.

3. The composition of claim 2, wherein said acyclic polyether polymer is selected from the group consisting of polyethylene glycol, polypropylene glycol, polyethylene glycol block copolymer, polyethyleneglycol mono (nonylphenyl) ether, and polytetramethylene glycol.

4. The composition of claim 2, wherein said acyclic polyether polymer is a polyether urethane.

5. The composition of claim 2, wherein said acyclic polyether polymer has a molecular weight in the range of from 200 to 100,000 daltons.