Multiple channel perfused manometry apparatus and a method of operation of such a device

• US 5,609,060 A
• Filed: 04/28/1995
• Issued: 03/11/1997
• Est. Priority Date: 04/28/1995
• Status: Expired due to Fees

• Current Assignee: Dentsleeve Pty., Limited
• Original Assignee: Dentsleeve Pty., Limited
• Inventors: Dent, John
• Primary Examiner(s): Millin, V.
• Assistant Examiner(s): Wieland, Robert N.
• Application Number:
  US08/431,052
• Time in Patent Office: 683 Days
• Field of Search: 73/700, 73/747
• US Class Current: 73/700
• CPC Class Codes: A61B 5/037 Measuring oesophageal pressure
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence

Abstract

An apparatus for multiple channel perfused gastrointestinal manometry particularly useful for animals and small children which avoids errors in pressure measurement due to air bubbles, particularly micro- bubbles in the channels. Achieved by the use of a carbon dioxide flush of the apparatus to displace the air bubbles in the manifold and manometry lines. The carbon dioxide is subsequently dissolved in the subsequent flow of manometric infusate.

Claims

1. A perfused manometry apparatus comprising a manometric line assembly having a plurality of channels therein with each channel terminating towards an operative end of the manometric line assembly at an opening in the line at a selected distance along the line, a manifold including a plurality of outlets for supplying a manometric infusate under pressure to each of the channels via the outlets at a manifold end of the manometric line assembly and the transducer associated with each channel to measure the pressure in each of the channels, the manifold including a flushing gas inlet to allow for to introduction of a flushing gas into the manifold and a infusate inlet to allow for introduction of the manometric infusate into the manifold, the first inlet means being connected with a source of flushing gas and the second inlet means being in connection with a source of manometric infusate under pressure.

2. A perfused manometry apparatus as in claim 1 further including a hydraulic resistance in each manifold outlet whereby to restrict the flow of manometric infusate into the channels.

3. A perfused manometry apparatus as in claim 2 wherein the hydraulic resistance comprises a capillary tube of a selected length to provide a selected resistance to flow.

4. A perfused manometry apparatus as in claim 1 wherein the manifold further includes a purge outlet.

5. A perfused manometry apparatus as in claim 4 wherein the flushing gas inlet and the infusate inlet are at one end of the manifold and the purge outlet is at the other end of the manifold.

6. A perfused manometry apparatus as in claim 1 wherein each manifold outlet includes a valve.

7. A perfused manometry apparatus as in claim 1 wherein the manometric infusate is de-gassed distilled water.

8. A perfused manometry apparatus as in claim 1 wherein the flushing gas is carbon dioxide.

9. A perfused manometry apparatus as in claim 1 in which the manometric line assembly is a micro-extrusion.

10. A perfused manometry apparatus as in claim 1 wherein the manometric line assembly has from four to twenty one channels.

11. A perfused manometry apparatus as in claim 1 wherein the manometric line assembly is a silicone rubber extrusion having the channels moulded therein.

12. A perfused manometry apparatus as in claim 1 wherein the channels have a diameter of from 0.20 mm to 0.80 mm.

13. A perfused manometry apparatus as in claim 1 wherein the source of manometric infusate under pressure is a pneumatically driven perfusion pump and a pneumatic source for the pump includes a pressure regulator.

14. A perfused manometry apparatus as in claim 1 wherein the source of carbon dioxide includes a pressure regulator.

15. A method of flushing a perfused manometry apparatus to remove air bubbles before introduction of a manometric infusate, the perfused manometry apparatus comprising a manometric line assembly having a plurality of channels therein with each channel terminating towards an operative end of the manometric line assembly at an opening in the line at a selected distance along the line, a manifold including a plurality of outlets for supplying a manometric infusate under pressure to each of the channels via the outlets at a manifold end of the manometric line assembly and the transducer associated with each channel to measure the pressure in each of the channels, the manifold including a flushing gas inlet to allow for introduction of a flushing gas into the manifold and a infusate inlet to allow for introduction of the manometric infusate into the manifold, the first inlet means being connected with a source of flushing gas and the second inlet means being in connection with a source of manometric infusate under pressure, the method comprising the steps of allowing a flow of the flushing gas through the first inlet into the manifold and subsequently into the transducers and into the channels of the manometric line assembly to exit out of the openings, stopping the flow of the flushing gas, and allowing a flow of manometric infusate into the manifold to replace the flushing gas throughout the apparatus, whereby any remaining the flushing gas is dissolved in the manometric infusate and carried out of the opening by the flow of infusate.

16. A method as in claim 15 wherein the carbon dioxide is allowed to flow for approximately two minutes.

17. A method as in claim 15 wherein the flow of manometric infusate subsequent to the flow of carbon dioxide is allowed for at least five minutes before the apparatus is used.

18. A method as in claim 15 wherein the manifold further includes a purge outlet and a purge outlet valve and the method includes the step of first opening the purge outlet valve and purging any liquid from the manifold by a flow of carbon dioxide.

19. A method as in claim 15 wherein the flushing gas is carbon dioxide.

20. A method as in claim 15 wherein the manometric infusate is degassed distilled water.