Cassette infusion system

• US 5,609,572 A
• Filed: 07/08/1994
• Issued: 03/11/1997
• Est. Priority Date: 11/23/1992
• Status: Expired due to Fees

• Current Assignee: Lang, Volker
• Original Assignee: Lang, Volker
• Inventors: Lang, Volker
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US08/256,326
• Time in Patent Office: 977 Days
• Field of Search: 604/65-67, 604/153, 604/246, 604/30-34, 604/49, 604/50, 604/51-53, 604/118, 604/247-249
• US Class Current: 604/22
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14224 Diaphragm type
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407

Abstract

A modular cassette infusion system for multiple infusions and the automatic administration of medicament. Sterile disposable cassettes are employed, which possess integral connections for the infusion lines, inlet valves, liquid distribution ducts, pump chambers, outlet valves, venting filters and chambers for the measurement of the infusion pressure. The system renders possible the infusion of 3, 6 or more different infusion solutions and medicaments held in disposable syringes via one or more small-volume pump chambers with outlet valve separately via a plurality thereof in parallel via only one vascular access point to the patient with the correct volume in a pulsating manner or in very small individual quantities substantially continuously in a quick succession one after the other without incompatible medicaments being mixed. After insertion in an universal, electromechanical and pneumatic or only electromechanical or furthermore electrohydraulic valve pump syringe actuating device the cassettes are operated with the aid of pressure surges. Since for control an electronic microprocessor control device is utilized, which can furthermore produce a printed record of an infusion and since a compatibility with other infusion equipment, as for example injection pumps is provided for, fixed programs and manual programming steps may solve the most types of infusion problem and provide for a substantial reduction in the work to be performed by nursing staff with an accompanying substantial reduction in costs. Additionally substantially enhanced improved patient safety is ensured.

Claims

1. A modular cassette infusion system for multiple infusions with a special suitability for intensive care comprising at least the following modules:

a) an infusion pump cassette comprising at least one pump chamber with an inlet duct, an inlet valve, an outlet duct and an outlet valve,

b) an infusion distributor cassette, which has two or more connections for infusion lines with associated inlet valves and following liquid distribution ducts, which open into one or more outlet connections,

c) a disposable medicament administration cassette comprising a plurality of medicament containers respectively connectable to one another and to an outlet connection of the medicament administration cassette,

wherein the outlet connections of the infusion distributor cassetter are connected to the inlet valve of the at least one infusion pump cassette via a connection hose,

the outlet connection of the medicament administration cassette is connected to an inlet valve of a further pump chamber via a further connection hose, the further pump chamber further comprising an outlet valve, an inlet duct and an outlet duct,

and the outlet ducts of the respective pump chambers are connectable to one another via their respective outlet valves.

2. The cassette infusion system as claimed in claim 1, characterized in that the infusion pump cassette additionally possesses a pressure measuring chamber and at least one venting filter.

3. The cassette infusion system as claimed in claim 1, characterized in that as an additional module the system comprises a valve, pump and syringe actuating device, which by means of plungers controls the valves arranged in the cassettes and the pump chambers and via metering plungers determines the infusion pressure.

4. The cassette infusion system as claimed in claim 1, characterized in that as an additional module the system comprises a microprocessor control device.

5. The cassette infusion system as claimed in claim 1, characterized in that the individual cassettes respectively possess bottom and covering plates of transparent molded plastic, which are fitted together in a sealing fashion by means of raised sealing rails on the covering plates and, respectively, the bottom plates, which surround all valve systems, open ducts, pump chambers and measuring chambers, and correspondingly shaped parts on the bottom and covering plates, and elastic valve plates, pump diaphragm and measuring diaphragm arranged between the bottom plate and, respectively, the covering plate are thrust together.

6. The cassette infusion system as claimed in claim 1, characterized in that the individual cassettes respectively possess bottom and covering plates of selectively transparent molded plastic, between which an elastic sealing plate is pressed.

7. The cassette infusion system as claimed in claim 1, characterized in that the infusion pump cassette additionally possesses a plurality of preferably cylindrically shaped cavities in its bottom plate and in its covering plate, into which cavities pump diaphragms provided with thrust plates, and pressure measuring plungers and, respectively, a pressure measuring diaphragm may be laid and into which a hydrophobic, air-permeable filter diaphragm is able to be pressed in a gas-tight manner.

8. The cassette infusion system as claimed in claim 1, characterized in that the valves are formed by the respective cassette covering plate with its integrally molded valve seats and inserted valve plates with a sealing edge and its associated supply and discharge ducts and the corresponding bottom plate with its valve plunger openings by welding or bonding of the valve seats and raised sealing surrounding the supply and discharge ducts.

9. The cassette infusion system as claimed in claim 1, characterized in that the pump chamber is passively filled by gravity infusion from one or more containers and in that the emptying thereof takes place actively by the displacement of a plunger.

10. The cassette infusion system as claimed in claim 1, characterized in that the pump chamber has a volume of 0.5 to 20 ml.

11. The cassette infusion system as claimed in claim 1, characterized in that the pump chamber comprises a non-extensible roll diaphragm and a thrust plate attached to the bottom thereof.

12. The cassette infusion system as claimed in claim 1, characterized in that a soft compression spring acts on the lower side of the roll diaphragm thrust plate and has an effect on the hydrostatic pressure necessary in the chamber filling phase.

13. The cassette infusion system as claimed in claim 1, characterized in that the pump chamber possesses a highly elastic planar diaphragm, a diaphragm with concertina folding or an elastic roll diaphragm with a thrust plate attached respectively to its lower side.

14. The cassetter infusion system as claimed in claim 1, comprising inductive or capacitive distance sensors for exactly measuring the level of filling of the pump chamber, which cooperate with the thrust plate of the pump diaphragm comprising ferromagnetic material.

15. The cassette infusion system as claimed in claim 1, characterized in that the chamber pressure of the pump chamber, which substantially is equal to the infusion pressure, is varied over a large range by changing the working pressure of a pump plunger medicament actuating cylinder.

16. The cassette infusion system as claimed in claim 1, characterized in that an inductive or capacitive distance sensor is provided in the valve plunger of the outlet valve, said sensor exactly indicating the opening and closing of the valve.

17. The cassette infusion system as claimed in claim 1, characterized in that hydrophobic venting filters, which are impermeable for liquids are provided in the infusion distributing cassette in the pump chamber cover and/or between the outlet valve of the pump chamber and the connection for the infusion hose leading to the patient.

18. The cassette infusion system as claimed in claim 1, characterized in that in the infusion pump cassette between the outlet valve from the pump chamber and the connection means for the infusion hose leading to the patient a cylindrical chamber is formed is covered over by an elastic sealing diaphragm on which a pressure sensor is engaged for the measurement of the infusion pressure.

19. The cassette infusion system as claimed in claim 1, characterized in that in the infusion distributing cassettes the valve seats, the liquid distributing ducts, the pump chambers, the pressure measuring diaphragm and the chambers with an air buffer function are provided respectively with surrounding sealing rails.

20. The cassette infusion system as claimed in claim 1, characterized in that the microprocessor control device causes the infusion liquid flow to the patient to be intermittent and with a distinct pulsating effect, the pump chamber being able to be completely emptied in one step with the respective outlet valve opened.

21. The cassette infusion system as claimed in claim 1, characterized in that the microprocessor control device ensures a fine control of the infusion liquid rate to the patient and in a substantially continuous manner by to stepped emptying of the pump chamber in substantially equal steps.

22. The cassette infusion system as claimed in claim 1, characterized in that the microprocessor control device causes a stepped evacuation of the pump chamber linked with an opening time of the outlet valve and consequently renders possible an exact discharge of part of a volume of the pump chamber.

23. The cassette infusion system as claimed in claim 4, characterized in that the microprocessor control device gives an alarm signal as a consequence of a disconnection of the hose.

24. The cassette infusion system as claimed in claim 1, characterized in that the microprocessor control device recognizes excessively long evacuation times for the infusion cassette pump, and in that accordingly an alarm is produced with an indication of an "obstruction".

25. The cassette infusion system as claimed in claim 1, characterized in that in the case of an excessively long filling time for the infusion cassette pump chamber the microprocessor control device causes an alarm with an indication that the infusion container is empty.

26. The cassette infusion system as claimed in claim 25, characterized in that the after the detection that an infusion container is emptied the microprocessor control device causes a switching over to an infusion container flushing solution and with a simultaneous reduction of the infusion rate to a minimum to keep open the vascular access.

27. The cassette infusion system as claimed in claim 1, characterized in that in the case of incompatibility of the infusion solutions the microprocessor control device ensures that such solutions are infused through one vascular access point, and an indifferent flushing solution is intermittently administered.

28. The cassette infusion system as claimed in claim 4, characterized in that the pump chamber evacuation rate is varied by the microprocessor control device in order to set the rate of infusion.

29. The cassette infusion system as claimed in claim 1, the medicament administration cassette accepts pressurized medicament containing disposable syringes, said syringes can be emptied by means of a special purpose valve and pump actuating device, which also cooperates with the infusion cassettes.

30. The cassette infusion system as claimed in claim 1, characterized in that a container filled with physiological sterile flushing liquid is connected with an inlet port of the medicament administration cassette, from which flushing liquid may emerge after each administration of a medicament in order to swill medicament residues from the medicament administration cassette, the connection hose and the infusion cassette into the vascular system of the patient.

31. The cassetter infusion system as claimed in claim 1, characterized in that the medicament administration cassette comprises a covering plate with molded on valve seats and sealing rails and a bottom plate with associated valve plunger openings and intermediately arranged, pressed in elastic valve plates.

32. The cassette infusion system as claimed in claim 1, characterized in that within the medicament administration cassette the openings provide in the center of the valve seats, apart from the opening in the inlet valve, respectively communicate with Luer standard connection ports, the respective Luer and standard connection ports representing the connection element for the different disposable syringes.

33. The cassette infusion system as claimed in claim 1, characterized in that within the medicament administration cassette the gage pressure in the medicament filled disposable syringes is produced by means of cocked springs and thrust slides thereof and by plunger and pistons of the disposable syringes.

34. The cassette infusion system as claimed in claim 1, characterized in that the universal valve, pump and syringe actuating device comprises two half shells, into which the valve and pump cylinders are directly mounted and simultaneously serve as a housing for the device.