Device for determining myocardial function and corresponding procedure and method

• US 5,609,612 A
• Filed: 12/13/1995
• Issued: 03/11/1997
• Est. Priority Date: 10/05/1993
• Status: Expired due to Term

• Current Assignee: Sorin Biomedica SpA (Snia SpA)
• Original Assignee: Sorin Biomedica Cardio Srl (LivaNova Plc)
• Inventors: Corbucci, Giorgio, Plicchi, Gianni, Garberoglio, Bruno
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US08/571,621
• Time in Patent Office: 454 Days
• Field of Search: 607/23, 607/17, 607/18, 607/3, 607/9, 607/6, 607/24
• US Class Current: 607/17
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

The device senses Natural Heart Acceleration (NHA), isolating at least one segment (t) thereof corresponding to an isovolumetric phase, such as isovolumetric contraction (P1, P2) and/or isovolumetric relaxation (P3, P4). Preferentially, the action of isolation of the aforesaid segment is made starting from the electrocardiogram (ECG) signal. Among other things, the device may be used to carry out pacing functions (pacemaker, defibrillator, pacer cardioverter defibrillator) and/or to pick up, possibly by telemetry, data on the myocardial function and/or also to control a system of drug administration.

Claims

1. A pacemaker comprising:

a natural heart acceleration sensor;

a signal generator coupled to the sensor to provide a signal representative of the natural heart acceleration;

a processor connected to receive the signal for determining a value indicative of a characteristic of the signal during a selected time segment and calculating the difference between the determined value and a reference value, the processor being operative to select a pacing rate based upon the difference between the determined value and the reference value;

a pulse generator responsive to the selected pacing rate to generate stimulating pulses corresponding to the selected pacing rate; and

at least one electrode for applying the stimulation pulses to at least one chamber of a patient'"'"'s heart.

2. The pacemaker of claim 1 wherein the reference value is constant.

3. The pacemaker of claim 1 wherein the reference value is programmable.

4. The pacemaker of claim 1 wherein the reference value is a dynamic value calculated by the processor as the average of the determined value over a predetermined time interval.

5. The pacemaker of claim 4 wherein the predetermined time interval is in the range of between about one hour and about 48 hours.

6. The pacemaker of claim 4 wherein the selected time segment is a phase of a cardiac cycle.

7. The pacemaker of claim 6 wherein the phase of the cardiac cycle is an isovolumetric phase.

8. The pacemaker of claim 6 wherein the phase of the cardiac cycle is the isovolumetric contraction phase.

9. The pacemaker of claim 8 wherein the characteristic of the signal comprises peak endocardial acceleration.

10. The pacemaker of claim 9 wherein the processor is operative to select a pacing rate which includes an AV delay based upon the determined value.

11. The pacemaker of claim 4 further comprising an ECG sensor to generate a signal representative of the ECG and wherein the time segment of the natural heart acceleration signal which is selected corresponds to a predetermined portion of the ECG signal.

12. The pacemaker of claim 11 wherein the predetermined time interval is in the range between about one hour and about 48 hours.

13. The pacemaker of claim 12 wherein the predetermined portion of the ECG signal comprises an isovolumetric phase of the cardiac cycle.

14. The pacemaker of claim 12 wherein the predetermined portion of the ECG signal comprises the isovolumetric contraction phase of the cardiac cycle.

15. The pacemaker of claim 14 wherein the characteristic of the signal comprises peak endocardial acceleration.

16. The pacemaker of claim 15 wherein the processor is operative to select a pacing rate which includes an AV delay based upon the determined value.

17. A pacemaker comprising:

a natural heart acceleration sensor;

means for generating a signal representative of the natural heart acceleration;

means for selecting at least one time segment of the natural heart acceleration signal;

means for processing the signal during the selected time segment to determine a value indicative of a characteristic of the signal during the selected time segment;

means for determining the difference between the determined value and a reference value;

means for selecting a pacing rate based upon the difference between the determined value and the reference value; and

means for providing stimulation pulses to at least one chamber of a patient'"'"'s heart at the selected pacing rate.

18. The pacemaker of claim 17 wherein the reference rate is constant.

19. The pacemaker of claim 17 wherein the reference rate is programmable.

20. The pacemaker of claim 17 wherein the reference value is a dynamic value calculated by the processing means as the average of the determined value over a predetermined time interval.

21. The pacemaker of claim 20 wherein the predetermined time interval is in the range of between about one hour and about 48 hours.

22. The pacemaker of claim 20 wherein the selected time segment is a phase of the cardiac cycle.

23. The pacemaker of claim 22 wherein the phase of the cardiac cycle is an isovolumetric phase.

24. The pacemaker of claim 22 wherein the phase of the cardiac cycle is the isovolumetric contraction phase.

25. The pacemaker of claim 24 wherein the characteristic of the signal comprises peak endocardial acceleration.

26. The pacemaker of claim 25 wherein the processing means selects a pacing rate which includes an AV delay based upon the determined value.

27. The pacemaker of claim 20 further comprising an ECG sensor to generate a signal representative of the ECG and wherein the selection of the time segment of the signal which is selected corresponds to a predetermined portion of the ECG signal.

28. The pacemaker of claim 27 wherein the predetermined time interval is in the range of between about one hour and about 48 hours.

29. The pacemaker of claim 28 wherein the phase of the cardiac cycle is an isovolumetric phase.

30. The pacemaker of claim 28 wherein the phase of the cardiac cycle is the isovolumetric contraction phase.

31. The pacemaker of claim 30 wherein the characteristic of the signal comprises peak endocardial acceleration.

32. The pacemaker of claim 31 wherein the processor is operative to select a pacing rate which includes an AV delay based upon the determined value.

33. A method for controlling a heart pacemaker comprising:

sensing a natural heart acceleration of a patient;

generating a signal representative of the natural heart acceleration;

selecting at least one time segment of the natural heart acceleration signal;

processing the signal during the selected time segment to determine a value indicative of a characteristic of the signal during the selected time segment;

determining the difference between the determined value and a reference value;

selecting a pacing rate based upon the difference between the determined value and the reference value; and

pacing at least one chamber of the patient'"'"'s heart at the selected pacing rate.

34. The method of claim 33 further comprising calculating the average of the determined value over a predetermined time interval and using the result to continually update the reference value.

35. The method of claim 34 wherein the predetermined time interval over which the average of the determined value is calculated is in the range between about one hour and about 48 hours.

36. The method of claim 34 wherein the time segment selected is a phase of the cardiac cycle.

37. The method of claim 36 wherein the phase of the cardiac cycle selected comprises the isovolumetric phase.

38. The method of claim 36 wherein the phase of the cardiac cycle selected comprises the isovolumetric contraction phase.

39. The method of claim 38 wherein the characteristic of the signal which is determined during the processing step comprises peak endocardial acceleration.

40. The method of claim 39 wherein the signal is processed to select a pacing rate which includes an AV delay based upon the determined value.

41. The method of claim 34 further comprising sensing the ECG of the patient'"'"'s heart and generating a signal representative of the ECG and wherein the time segment of the natural heart acceleration signal is selected to correspond with a predetermined portion of the ECG signal.

42. The method of claim 41 wherein the predetermined time interval over which the average of the determined value is calculated is in the range between about one hour and about 48 hours.

43. The method of claim 42 wherein the time segment selected is a phase of the cardiac cycle.

44. The method of claim 43 wherein the phase of the cardiac cycle selected comprises an isovolumetric phase.

45. The method of claim 43 wherein the phase of the cardiac cycle selected comprises the isovolumetric contraction phase.

46. The method of claim 45 wherein the characteristic of the signal which is determined during the processing step comprises peak endocardial acceleration.