Coated implantable medical device
First Claim
1. An implantable medical device (10) comprising:
- a structure (12) adapted for introduction into a patient, the structure (12) being composed of a base material (14);
at least one layer (18) of a bioactive material positioned over the structure (12);
at least one porous layer (20) positioned over the bioactive material (18), composed of a polymer applied by vapored deposition or plasma deposition, and being of a thickness adequate to provide a controlled release of the bioactive material; and
at least one additional coating layer (16) applied to the base material (14) and being less porous than, but composed of the same polymer as, at least one porous layer (20).
2 Assignments
0 Petitions
Accused Products
Abstract
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material positioned over the structure 12; and at least one porous layer 20 positioned over the bioactive material layer 18. Preferably, the structure 12 is a coronary stent, and the bioactive material is at least one of heparin, dexamethasone or a dexamethasone derivative. The device 10 includes layers 18 and 22 of heparin and dexamethasone, the layer 22 of dexamethasone being positioned above the layer 18 of heparin. The layers of bioactive material also can be individual materials or a combination of different materials. Unexpectedly, the more soluble heparin markedly promotes the release of the less soluble dexamethasone above it. The porous layer 20 is composed of a polymer applied by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyimide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor.
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Citations
19 Claims
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1. An implantable medical device (10) comprising:
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a structure (12) adapted for introduction into a patient, the structure (12) being composed of a base material (14); at least one layer (18) of a bioactive material positioned over the structure (12); at least one porous layer (20) positioned over the bioactive material (18), composed of a polymer applied by vapored deposition or plasma deposition, and being of a thickness adequate to provide a controlled release of the bioactive material; and at least one additional coating layer (16) applied to the base material (14) and being less porous than, but composed of the same polymer as, at least one porous layer (20). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An implantable medical device (10) comprising:
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a structure (12) adapted for introduction into a patient, the structure (12) being composed of a base material (14); at least one layer (18) of a bioactive material positioned over the structure (12); at least one porous layer (20) positioned over the bioactive material (18), composed of a polymer applied by vapored deposition or plasma deposition, and being of a thickness adequate to provide a controlled release of the bioactive material; and wherein said device (10) comprises an additional layer of a different bioactive material (22) positioned over the structure (12). - View Dependent Claims (17, 18, 19)
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Specification