Insecticide composition of rotenone microspheres

• US 5,609,878 A
• Filed: 01/05/1996
• Issued: 03/11/1997
• Est. Priority Date: 06/05/1991
• Status: Expired due to Fees

• Current Assignee: Jean Gueyne, Marie-Christine Seguin
• Original Assignee: Jean Gueyne, Marie-Christine Seguin
• Inventors: Seguin, Marie-Christine, Gueyne, Jean
• Primary Examiner(s): Levy, Neil S.
• Application Number:
  US08/583,534
• Time in Patent Office: 431 Days
• Field of Search: 424/490, 424/497, 424/78.31, 424/78.35, 424/417, 424/405, 424/418, 424/408, 514/65, 514/68, 514/70, 514/72, 514/73
• US Class Current: 424/408
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/12 Powders or granules A01N25/26 takes precedence
• CPC Class Codes: A01N 25/16 Foams
• CPC Class Codes: A01N 25/28 Microcapsules or nanocapsules
• CPC Class Codes: A01N 43/90 having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• CPC Class Codes: A01N 65/20 Fabaceae or Leguminosae [Pea or Legume family], e.g. pea, lentil, soybean, clover, acacia, honey locust, derris or millettia
• CPC Class Codes: A61K 31/35 having six-membered rings with one oxygen as the only ring hetero atom
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
• CPC Class Codes: Y10S 977/915 Therapeutic or pharmaceutical composition
• CPC Class Codes: Y10S 977/926 Topical chemical, e.g. cosmetic or sunscreen

Abstract

Insecticide composition, especially a pediculicide, comprising as active agent, rotenone or reduced rotenone. The composition is characterized in that said agent is bound to small polymer spherules. The retonone and/or reduced is preferably at least 90% pure. The composition may be in the form of a suspension, an emulsion, a powder, a paste, a cream or a foam and the like. The novel composition is useful in the treatment of parasites in both humans and animals.

Claims

1. An insecticide composition comprising:

approximately 0.05% to 10% by weight of at least one active agent selected from the group consisting of rotenone, reduced rotenone and a mixture of rotenone and reduced rotenone, wherein said active agent is at least 90% pure;

microscopic polymer spherules, wherein said active agent is adsorbed to the surface of said spherules and wherein said polymer is selected from the group consisting of polysaccharide, polyamide, polyalkylene, polyarylalkylene, polyalkylidene and polysiloxane; and

approximately 80 to 95.5% of a carrier or diluent.

2. A composition according to claim 1, wherein said carrier or diluent comprises a solvent selected from the group consisting of ester of phthalic, benzoic, benzylic or mellitic acid, a C₂ to C₈ alkylene glycol and a linear or cyclic polyalkyl-siloxane.

3. A composition according to claim 2, wherein said solvent is selected from the group consisting of lauryl benzoate, ethanol and hexamethyl-disiloxane.

4. A composition according to claim 1 wherein said active agent is at least 99% pure.

5. A composition according to claim 1 wherein said spherules have dimensions of less than approximately 1000 nm.

6. A composition according to claim 1 wherein said spherules have dimensions of approximately 50-500 nm.

7. A composition according to claim 1 wherein said composition is in a form selected from the group consisting of a paste, a cream and a foam.

8. A method of destroying parasites on a human or animal body, comprising the step of:

applying to a human or animal in need of such treatment a composition comprising;

approximately 0.05% to 10% by weight of at least one active agent selected from the group consisting of rotenone, reduced rotenone and a mixture of rotenone and reduced rotenone, wherein said active agent is at least 90% pure;

microscopic polymer spherules, wherein said active agent is adsorbed to the surface of said spherules and wherein said polymer is selected from the group consisting of polysaccharide, polyamide, polyalkylene, polyarylalkylene, polyalkylidene and polysiloxane; and

a carrier, diluent or adjuvant.

9. A method according to claim 8 wherein said carrier or diluent comprises a solvent selected from the group consisting of ester of phthalic, benzoic, benzylic, or mellitic acid, a C₂ to C₈ alkylene-glycol and a linear or cyclic polyalkyl-siloxane.

10. A method according to claim 9 wherein said solvent is selected from the group consisting of lauryl benzoate, ethanol and hexamethyl-disiloxane.

11. A method according to claim 8 wherein said active agent is at least 99% pure.

12. A method according to claim 8 wherein approximately 0.1% to 3% by weight of said spherules are present.

20. A method as recited in claim 8 wherein said adjuvant is selected from the group consisting of terpene, phenol and a mixture of terpene and phenol.

13. A method of preparing a composition comprising the step of:

dissolving approximately 0.05% to 10% by weight of at least one active agent selected from the group consisting of rotenone, reduced rotenone and a mixture of rotenone and reduced rotenone, wherein said active agent is at least 90% pure in a solvent to form a first solution;

providing microscopic polymer spherules, wherein said polymer is selected from the group consisting of polysaccharide, polyamide, polyalkylene, polyarylalkylene, polyalkylidene and polysiloxane; and

mixing said first solution and said spherules so that said active agent is adsorbed to the surface of said spherules.

14. A method according to claim 13 wherein said active agent and said spherules are mixed in the presence of a solvent selected from the group consisting of ester of phthalic, benzoic, benzylic, or mellitic acid, a C₂ to C₈ alkylene-glycol and a linear or cyclic polyalkyl-siloxane.

15. A method as recited in claim 13 wherein a surface active agent or a third solvent is mixed into said composition.

16. A method as recited in claim 14 further comprising the step of removing the liquid of the composition so that a powdered composition is produced.

17. A method as recited in claim 14 further comprising the step of mixing the composition with a compound selected from the group consisting of a cream, a paste and a foam.

18. A composition obtainable by a process comprising the steps of:

dissolving approximately 0.05% to 10% by weight of at least one active agent selected from the group consisting of rotenone, reduced rotenone and a mixture of rotenone and reduced rotenone, wherein said active agent is at least 90% pure in a solvent to form a first solution;

providing microscopic polymer spherules, wherein said polymer is selected from the group consisting of polysaccharide, polyamide, polyalkylene, polyarylalkylene, polyalkylidene and polysiloxane; and

mixing said first solution and said spherules so that said active agent is adsorbed to the surface of said spherules.

19. A composition as recited in claim 18 wherein said process further comprises the step of removing the liquid of the composition so that a powdered composition is produced.