Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
First Claim
1. A compound of the formula ##STR26## wherein Q is a group of the formula --CH2 --CH2 --, --CH═
- CH-- or ##STR27## R and R'"'"' are each independently C1 -C4 -alkyl;
R1 is thienyl, phenyl, cyclopentyl or cyclohexyl; and
,X- is a physiologically acceptable anion.
2 Assignments
0 Petitions
Accused Products
Abstract
Compounds of the formula ##STR1## of which, in exemplary compounds, the thienyl group is attached via the 2-position and:
(a) A is 3α-(6β, 7β-epoxy)-tropanyl methobromide and R1 is 2-thienyl;
(b) A is 3α-(6, 7dehydro)-tropanyl methobromide and R1 is 2-thienyl;
(c) A is 3β-tropanyl methobromide and R1 is 2-thienyl; and,
(d) A is 3α-(N-isopropyl)-nortropanyl methobromide and R1 is cyclopentyl.
These are anticholinergics. Administered by inhalation, they are useful for the treatment of chronic obstructive bronchitis or slight to moderately severe asthma. Administered by the intravenous or oral routes, they are useful for the treatment of vagally induced sinus bradycardia.
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Citations
16 Claims
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1. A compound of the formula ##STR26## wherein Q is a group of the formula --CH2 --CH2 --, --CH═
- CH-- or ##STR27## R and R'"'"' are each independently C1 -C4 -alkyl;
R1 is thienyl, phenyl, cyclopentyl or cyclohexyl; and
,X- is a physiologically acceptable anion. - View Dependent Claims (2, 3, 4, 11, 12, 13, 14, 15, 16)
- CH-- or ##STR27## R and R'"'"' are each independently C1 -C4 -alkyl;
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5. A compound of the formula ##STR29## wherein X- is a physiologically acceptable anion.
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6. A compound of the formula ##STR30## wherein X- is a physiologically acceptable onion.
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7. A compound of the formula ##STR31##
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8. A compound of the formula ##STR32## wherein R1 is 2-thienyl and A is 3α
- -(6,7-dehydro)-tropanyl methobronide.
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9. A compound of the formula ##STR33## wherein R1 is 2-thienyl and A is 3β
- -tropanyl methobromide.
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10. A compound of the formula ##STR34## wherein R1 is cyclopentyl and A is 3α
- -(N-isopropyl)-nortropanyl methobromide.
Specification