Risperidone pamoate

• US 5,612,346 A
• Filed: 09/22/1995
• Issued: 03/18/1997
• Est. Priority Date: 04/28/1993
• Status: Expired due to Term

• Current Assignee: Janssen Pharmaceuticals, Inc. (Johnson & Johnson), the united states of america as represented by the secretary of the navy
• Original Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Inventors: Mesens, Jean L., Peeters, Jozef
• Primary Examiner(s): Grumbling, Matthew V.
• Application Number:
  US08/522,422
• Time in Patent Office: 543 Days
• Field of Search: 514/258, 544/282
• US Class Current: 514/259.41
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: C07C 65/11 with carboxyl groups on a condensed ring system containing two rings
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

A compound which is a pamoate acid addition salt of risperidone, compositions comprising the same and processes for preparing said compound and compositions.

Claims

1. A compound which is a pamoate acid addition salt of risperidone.

2. A compound according to claim 1 having the formula ##STR2##

3. A composition comprising a pharmaceutically acceptable carrier and as active ingredient a pharmaceutically effective amount of a compound as claimed in claim 1.

4. A composition according to claim 3 in an injectable dosage form.

5. A composition according to claim 4 which takes the form of an aqueous suspension.

6. A composition according to claim 5 further comprising benzyl alcohol, a sorbitan ester and water.

7. A composition according to claim 6 further comprising a cellulose derivative.