Method for sleep induction

• US 5,612,380 A
• Filed: 01/05/1995
• Issued: 03/18/1997
• Est. Priority Date: 09/27/1994
• Status: Expired due to Fees

• Current Assignee: The Scripps Research Institute
• Original Assignee: The Scripps Research Institute
• Inventors: Boger, Dale, Cravatt, Ben, Lerner, Richard A., Henriksen, Steven J., Siuzdak, Gary E.
• Primary Examiner(s): JORDAN, KIMBERLY R
• Application Number:
  US08/369,036
• Time in Patent Office: 803 Days
• Field of Search: 514/625, 514/627, 514/923
• US Class Current: 514/627
• CPC Class Codes: A61K 31/16 Amides, e.g. hydroxamic acids
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Sleep may be induced by administration of fatty acid primary amides, including cis-9,10-octadecenoamide. Furthermore, sleep deprivation may be assayed by analyzing cerebrospinal fluid with respect to the presence of fatty acid primary amides, including cis-9,10-octadecenoamide. The presence of cis-9,10-octadecenoamide in cerebrospinal fluid is correlated with comparative sleep deprivation.

Claims

1. A method for inducing sleep comprising the step of administering a fatty acid primary amide to a subject.

2. A method for inducing sleep as described in claim 1 wherein the fatty acid primary amide includes an alkyl chain having an unsaturation.

3. A method for inducing sleep as described in claim 2 wherein the fatty acid primary amide has the following formula:

space="preserve" listing-type="equation">NH.sub.2 C(O)(CH.sub.2).sub.(6≧

n≦

11) CH═

CH(CH.sub.2).sub.(8≧

n≦

5) CH.sub.3.

4. A method for inducing sleep as described in claim 3 wherein the unsaturation of the alkyl chain has a cis configuration.

5. A method for inducing sleep as described in claim 3 wherein the unsaturation of the alkyl chain has a trans configuration.

6. A method for inducing sleep as described in claim 3 wherein the fatty acid primary amide is cis-9,10-octadecenoamide.

7. A method for inducing sleep as described in claim 3 wherein the fatty acid primary amide is trans-9,10-octadecenoamide.

8. A method for inducing sleep as described in claim 3 wherein the fatty acid primary amide is cis-8,9-octadecenoamide.

9. A method for inducing sleep as described in claim 3 wherein the fatty acid primary amide is cis-11,12-octadecenoamide.

10. A method for inducing sleep as described in claim 3 wherein the fatty acid primary amide is cis-13,14-docosenoamide.

11. A method for inducing sleep as described in claim 1 wherein the fatty acid primary amide is administered by a method selected from the group of methods consisting of intraperitoneal injection (ip), subcutaneous injection (sc), intramuscular injection (im), peroral ingestion (po), spinal injection, and cranial injection.

12. A method for inducing sleep as described in claim 1 wherein the dosage ranges from 1 milligram to 10 grams per day.