Nuclear factors and binding assay
First Claim
Patent Images
1. An isolated human nuclear factor of activated T-cells, hNFAT, protein comprising hNFATp1 (SEQ ID NO:
- 2), hNFATp2 (SEQ ID NO;
2, residues 220-921 ), hNFAT3 (SEQ ID NO;
6), hNFAT4b (SEQ ID NO;
10) or hNFAT4c (SEQ ID NO;
12).
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Accused Products
Abstract
The invention provides methods and compositions for identifying pharmacological agents useful in the diagnosis or treatment of disease associated with the expression of a gene modulated by a transcription complex containing at least a human nuclear factor of activated T-cells (hNFAT). The materials include a family of hNFAT proteins, active fragments thereof, and nucleic acids encoding them. The methods are particularly suited to high-throughput screening where one or more steps are performed by a computer controlled electromechanical robot comprising an axial rotatable arm.
22 Citations
6 Claims
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1. An isolated human nuclear factor of activated T-cells, hNFAT, protein comprising hNFATp1 (SEQ ID NO:
- 2), hNFATp2 (SEQ ID NO;
2, residues 220-921 ), hNFAT3 (SEQ ID NO;
6), hNFAT4b (SEQ ID NO;
10) or hNFAT4c (SEQ ID NO;
12). - View Dependent Claims (2, 3, 4, 5, 6)
- 2), hNFATp2 (SEQ ID NO;
Specification
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Current AssigneeAmgen Inc.
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Original AssigneeTularik, Inc. (Amgen Inc.)
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InventorsHoey, Timothy
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Primary Examiner(s)Fleisher, Mindy
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Assistant Examiner(s)MCKELVEY, TERRY ALAN
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Application NumberUS08/396,479Time in Patent Office747 DaysField of Search530/350US Class Current530/350CPC Class CodesC07K 14/4702 Regulators; Modulating acti...G01N 33/5008 for testing or evaluating t...G01N 33/5011 for testing antineoplastic ...G01N 33/505 involving T-cellsG01N 33/5091 for testing the pathologica...
