Apparatus for applying medicament to an eye

• US 5,613,957 A
• Filed: 03/11/1994
• Issued: 03/25/1997
• Est. Priority Date: 12/02/1991
• Status: Expired due to Term

• Current Assignee: Dr Py Institute LLC
• Original Assignee: Daniel Py
• Inventors: Py, Daniel
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): RUHL, DENNIS WILLIAM
• Application Number:
  US08/209,957
• Time in Patent Office: 1,110 Days
• Field of Search: 604/187, 604/289, 604/294-302, 222/321, 222/420, 222/494
• US Class Current: 604/294
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61M 35/003 Portable hand-held applicators having means for dispensing or spreading integral media hand-held massage devices with liquid delivery A61H7/003
• CPC Class Codes: B05B 11/0072 A valve member forming part of an outlet opening
• CPC Class Codes: B05B 11/1001 Piston pumps B05B11/1087, B05B11/1088, B05B11/109 take precedence
• CPC Class Codes: B05B 11/107 Gate valves; Sliding valves
• CPC Class Codes: B05B 11/1074 located outside pump chambers
• CPC Class Codes: B05B 11/1095 with movable suction side

Abstract

An apparatus is used to apply medicament to an eye and stores the medicament in a medicament chamber. A nozzle is coupled in fluid communication with the medicament chamber and is formed by an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion. A tight interface is defined between the inner nozzle portion and the outer nozzle portion and is normally in a closed position to prevent the passage of medicament through the nozzle. The interface opens in response to the flow of medicament of sufficient pressure into it to permit the passage of medicament through the nozzle for release into the eye.

Claims

1. An apparatus for applying medicament to an eye, comprising:

a medicament chamber for holding medicament; and

a nozzle coupled in fluid communication with the medicament chamber, the nozzle including an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion to define an interface at a region of contact between the inner and outer nozzle portions, the region of contact preventing passage of medicament through the nozzle, wherein a flow of medicament of sufficient pressure may be forced through the interface of the nozzle to at least partially sever said region of contact and release medicament into the eye with the region of contact being restored upon said release of medicament, and wherein the outer nozzle portion is more flexible than the inner nozzle portion for facilitating severing of the region of contact in response to a flow of medicament of sufficient pressure through the nozzle interface and the outer nozzle portion has a thickness which continuously decreases from a first point in a direction toward a tip of the nozzle.

2. An apparatus as defined in claim 1, further comprising a piston member for pressurizing medicament to flow through the interface for release into the eye.

3. An apparatus as defined in claim 2, wherein the piston member is seated within a piston cavity coupled in fluid communication with the nozzle and the medicament chamber, and the piston member is moveable within the piston cavity to cause medicament within the piston cavity to flow through the interface for release into the eye, the apparatus further comprising means for permitting aspiration of medicament from the medicament chamber to the piston cavity upon an upward stroke of the piston member.

4. An apparatus as defined in claim 3, wherein the piston cavity is dimensioned to release a predetermined volume of medicament into the eye.

5. An apparatus as defined in claim 3, wherein the piston cavity is coupled in fluid communication with the medicament chamber by at least one aperture, and the piston member causes the medicament within the piston cavity to flow through the interface upon passing the at least one aperture when moved toward the nozzle.

6. An apparatus as defined in claim 2, further comprising a piston body coupled to the piston member for driving the piston member to release medicament by moving the piston body.

7. An apparatus as defined in claim 6, further comprising a flexible means coupled between the piston body and the nozzle for permitting the piston body to move relative to the nozzle.

8. An apparatus as defined in claim 7, wherein the flexible means includes a bellows.

9. An apparatus as defined in claim 1, further comprising an actuating member for pressurizing medicament to flow into the interface for release into the eye.

10. An apparatus as defined in claim 9, further comprising a body member coupled to the actuating member and defining at least a portion of the medicament chamber.

11. An apparatus as defined in claim 10, further comprising a flexible portion coupled between the body member and the nozzle for permitting the body member and the actuating member to be moved relative to the nozzle.

12. An apparatus as defined in claim 11, wherein the flexible portion includes a bellows.

13. An apparatus as defined in claim 9, wherein the actuating member is coupled to a shaft member and moveable along the shaft member to pressurize medicament to flow into the interface.

14. An apparatus as defined in claim 13, wherein the shaft member has a bore therein which receives a rod member, the rod member and the shaft member defining at least one channel therebetween, the channel being coupled in fluid communication with the interface for directing the flow of pressurized medicament upon movement of the actuating member along the shaft member into the interface.

15. An apparatus as defined in claim 13, further comprising a flange member coupled to the shaft member for directing the flow of medicament, which is pressurized upon movement of the actuating member, through the interface.

16. An apparatus as defined in claim 15, further comprising at least one wall defining a cavity coupled in fluid communication with the medicament chamber for receiving the flange member upon movement of the actuating member, wherein medicament within the cavity is pressurized by the actuating member and directed into the interface.

17. An apparatus as defined in claim 16, wherein the at least one wall defines at least one aperture for coupling the cavity in fluid communication with the medicament chamber, and the medicament within the cavity is directed into the interface upon movement of the actuating member toward the flange member.

35. An apparatus as defined in claim 3, wherein the at least one wall defines at least one aperture for coupling the cavity in fluid communication with the chamber, and fluid within the cavity is directed into the nozzle upon movement of the actuating member toward the flange member.

18. An apparatus for applying fluid drops to an eye, comprising:

a fluid container containing a supply of a fluid; and

a nozzle coupled to the container, the nozzle defined by a first portion coupled to a second portion, wherein the first and second portions define an interface therebetween normally oriented to create a region of contact between the first and second portions which substantially prevents a flow of fluid through the nozzle, the region of contact being at least partially severed in response to the flow of fluid of sufficient pressure into the interface to permit the fluid to flow through the nozzle and the region of contact being restored upon release of the fluid through the nozzle, wherein the second nozzle portion is made of a material more flexible than the first nozzle portion for facilitating severing the region of contact in response to a flow of fluid into the interface and wherein the second nozzle portion has a thickness which continuously decreases from a first point in a direction toward a tip of the nozzle.

19. An apparatus as defined in claim 18, further comprising a piston member for pressurizing fluid to flow through the interface for release into the eye.

20. An apparatus as defined in claim 19, wherein the piston member is seated within a piston cavity coupled in fluid communication with the nozzle, and the piston member is moveable within the piston cavity to cause fluid within the piston cavity to flow through the interface for release into the eye.

21. An apparatus as defined in claim 19, further comprising a piston body coupled to the piston member for driving the piston member to release fluid by moving the piston body.

22. An apparatus as defined in claim 18, wherein the fluid is medicament for treating the eye.

23. An apparatus as defined in claim 18, further comprising an actuating member for pressurizing fluid to flow into the interface for release into the eye.

24. An apparatus as defined in claim 23, wherein the actuating member is coupled to a shaft member and moveable along the shaft member to pressurize fluid to flow into the interface.

25. An apparatus as defined in claim 24, wherein the shaft member has a bore therein which receives a rod member, the rod member and the shaft member defining at least one channel therebetween, the channel being coupled in fluid communication with the interface for directing the flow of pressurized fluid into the interface upon movement of the actuating member along the shaft member.

26. An apparatus as defined in claim 24, further comprising a flange member coupled to the shaft member for directing the flow of fluid pressurized toward the interface upon movement of the actuating member.

27. An apparatus as defined in claim 26, further comprising at least one wall defining a cavity coupled in fluid communication with the fluid container, the cavity receiving the flange member upon movement of the actuating member toward the flange member, wherein fluid within the cavity is pressurized by the actuating member and directed into the interface.

28. An apparatus for dispensing a fluid in drops, comprising:

a fluid vial containing a supply of fluid; and

a nozzle coupled to the vial, the nozzle including an inner member coupled in an abutting relationship with an outer member, the inner member and the outer member defining an interface at the region where they abut, the region of abutment being at least partially severed in response to a flow of fluid of sufficient pressure into the interface to dispense the fluid from the nozzle and the region of abutment being restored upon the release of the fluid to prevent a flow of fluid from outside the nozzle into the apparatus, wherein the outer member is made of a material more resilient in comparison to the inner member for facilitating severing of the region of abutment in response to a flow of fluid into the interface and wherein the outer member has a thickness which continuously decreases from a first point in a direction toward a tip of the nozzle.

29. An apparatus as defined in claim 28, wherein the fluid is a medicament for release into to an eye.

30. An apparatus as defined in claim 28, further comprising means for supplying a substantially predetermined quantity of fluid to the interface for release through the nozzle.

31. An apparatus as defined in claim 28, further comprising means for pressurizing fluid flowing into the interface to at least partially sever the region of abutment between the inner member and the outer member.

32. An apparatus as defined in claim 28, further comprising an actuating member for pressurizing fluid to flow through the interface.

33. An apparatus for dispensing fluid drops into an eye, comprising a substantially fluid-tight chamber and defining a nozzle coupled in fluid communication with the chamber for dispensing fluid drops through the nozzle into the eye, a shaft member enclosed within the chamber, an actuating member coupled to the shaft member and enclosed within the chamber for moving along the shaft member to pump a portion of a volume of fluid within the chamber through the nozzle into the eye while preventing contamination of fluid remaining within the chamber, a flange member fixedly coupled to the shaft member and enclosed within the chamber for directing the flow of pressurized fluid through the nozzle upon movement of the actuating member, and at least one wall enclosed within the chamber and defining a cavity coupled in fluid communication with the chamber, the cavity receiving the flange member therein upon movement of the actuating member wherein fluid within the cavity is pressurized by the actuating member and directed into the nozzle, wherein the nozzle includes a first portion coupled to a second portion, and the first and second portions define an interface at a region where they contact one another, the region of contact substantially preventing the flow of fluid through the nozzle, the region of contact being at least partially severed in response to a flow of fluid of sufficient pressure into the interface to permit the fluid to flow through the nozzle and the region of contact being restored upon release of the fluid through the nozzle.

34. An apparatus as defined in claim 33, wherein the shaft member defines at least one channel coupled in fluid communication with the nozzle for directing the flow of pressurized fluid into the nozzle upon movement of the actuating member along the shaft member.

36. An apparatus as defined in claim 33, wherein the fluid is medicament for release into the eye.

37. An apparatus for applying medicament to an eye, comprising:

a medicament chamber for holding medicament;

a nozzle coupled in fluid communication with the medicament chamber, the nozzle including an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion to define an interface at a region of contact between the inner and outer nozzle portions, the region of contact preventing passage of medicament through the nozzle, wherein a flow of medicament of sufficient pressure may be forced through the interface of the nozzle to at least partially sever said region of contact and release medicament into the eye with the region of contact being restored upon said release of medicament;

a hollow member defining a piston cavity therein;

a piston member for pressurizing medicament to flow through the interface for release into the eye, the piston member being slidably disposed in the hollow member and the piston member having a flexible rim projecting therefrom which makes slidable, sealing contact with an interior surface of the hollow member;

a piston body coupled to the piston member for driving the piston member to release medicament by moving the piston body; and

a flexible bellows coupled between the piston body and the nozzle for permitting the piston body to move relative to the nozzle.

38. An apparatus for applying medicament to an eye, comprising:

a medicament chamber for holding medicament;

a nozzle coupled in fluid communication with the medicament chamber, the nozzle including an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion to define an interface at a region of contact between the inner and outer nozzle portions, the region of contact preventing passage of medicament through the nozzle, wherein a flow of medicament of sufficient pressure may be forced through the interface of the nozzle to at least partially sever said region of contact and release medicament into the eye with the region of contact being restored upon said release of medicament;

an actuating member coupled to a shaft member and moveable along the shaft member to pressurize medicament to flow into the interface and at least partially sever the region of contact, wherein the shaft member has a bore therein which receives a rod member, the rod member and the shaft member defining at least one channel therebetween, the channel being coupled in fluid communication with the interface for directing the flow of pressurized medicament into the interface upon movement of the actuating member along the shaft member;

a flange member coupled to the shaft member for directing the flow of medicament, which is pressurized upon movement of the actuating member, through the interface; and

at least one wall defining a cavity coupled in fluid communication with the medicament chamber for receiving the flange member upon movement of the actuating member toward the flange member whereupon medicament within the cavity is pressurized by the actuating member and directed into the interface, said at least one wall defining at least one aperture for coupling the cavity in fluid communication with the medicament chamber.

39. An apparatus for applying fluid drops to an eye, comprising:

a fluid container containing a supply of a fluid;

a nozzle coupled to the container, the nozzle defined by a first portion coupled to a second portion, wherein the first and second portions define an interface therebetween normally oriented to create a region of contact between the first and second portions which substantially prevents a flow of fluid through the nozzle, the region of contact being at least partially severed in response to the flow of fluid of sufficient pressure into the interface to permit the fluid to flow through the nozzle and the region of contact being restored upon release of the fluid through the nozzle;

an actuating member coupled to a shaft member and moveable along the shaft member for pressurizing fluid to flow into the interface for release into the eye; and

a flange member fixedly coupled to the shaft member for directing the flow of fluid pressurized toward the interface upon movement of the actuating member.