Bioartificial endocrine device
First Claim
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1. A bioartificial pancreas for releasing insulin in a recipient patient, comprising:
- a matrix containing an insulin producing cellular moiety; and
capsule means enveloping said matrix comprising a polymeric membrane selected from the group consisting of poly-para-xylyene, poly-monochloro-xylyene, and poly-dichloro-xylyene, said polymeric membrane having a porosity blocking passage therethrough of immunogenic agents and permitting passage therethrough of nutrients for said cellular moiety and the insulin produced thereby.
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Abstract
A device for the effective release of hormones wherein a matrix containing a hormone producing cellular moiety is encapsulated with a non-immunogenic polymeric material of poly-para-xylyene having a membrane portion with a porosity blocking passage therethrough of immunogenic agents and permitting passage therethrough of effective nutrients for said cellular moiety and the hormone produced thereby.
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Citations
14 Claims
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1. A bioartificial pancreas for releasing insulin in a recipient patient, comprising:
- a matrix containing an insulin producing cellular moiety; and
capsule means enveloping said matrix comprising a polymeric membrane selected from the group consisting of poly-para-xylyene, poly-monochloro-xylyene, and poly-dichloro-xylyene, said polymeric membrane having a porosity blocking passage therethrough of immunogenic agents and permitting passage therethrough of nutrients for said cellular moiety and the insulin produced thereby. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- a matrix containing an insulin producing cellular moiety; and
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11. A bioartificial pancreas comprising:
- capsule means for containing insulin producing cells formed of a biocompatible material including a permeable membrane formed of poly-para-xylyene, said membrane having a thickness less than about 5,000 Angstroms and permitting the passage therethrough of insulin.
- View Dependent Claims (12)
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13. A bioartificial pancreas, comprising:
- a matrix for releasing insulin from a cellular moiety; and
capsule means enveloping said matrix comprising a paraxylyene polymeric membrane having a porosity blocking passage therethrough of immunogenic agents and permitting passage therethrough of insulin from said cellular moiety, said membrane having a molecular weight porosity of between about 5,000 and 500,000. - View Dependent Claims (14)
- a matrix for releasing insulin from a cellular moiety; and
Specification