Compositions and methods for animal husbandry and for treating gastrointestinal disorders

• US 5,614,501 A
• Filed: 05/04/1995
• Issued: 03/25/1997
• Est. Priority Date: 07/21/1994
• Status: Expired due to Term

• Current Assignee: University of Montana (University of Montana System)
• Original Assignee: University of Montana (University of Montana System)
• Inventors: Richards, Geoffrey N.
• Primary Examiner(s): Geist, Gary
• Assistant Examiner(s): Williams, Rosalynd A.
• Application Number:
  US08/434,492
• Time in Patent Office: 691 Days
• Field of Search: 514/22, 514/23, 514/53, 514/57, 514/458, 514/867
• US Class Current: 514/22
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 31/717 Celluloses
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system

Abstract

Compositions containing hemicelluloses in combination with polyphenols, methods of preparing the compositions, and methods of treating humans or animals with the composition are provided. Also provided is a method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal by administering an effective amount of the composition to the animal. The hemicelluloses preferably are not consumed by human alimentary enzymes or harmful bacteria, such as putrefactive or pathogenic bacteria, in the gastrointestinal tract, and are consumed by beneficial bacteria, such as bifidobacteria, in the gastrointestinal tract. The polyphenols preferably decrease the amount of harmful bacteria in the gastrointestinal tract. The compositions can optionally contain a carrier or be used as a feed addition and are administered to humans or other animals in an amount sufficient to treat the gastrointestinal disorder.

Claims

1. A method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal, the method comprising administering to the animal an effective amount of a composition comprising an extract of wood of a tree of the genus Larix comprising arabinogalactan and a polyphenol, wherein thee arabinogalactan is water soluble, resists digestion by animal alimentary enzymes, and is selectively digested by Bifidobacteria.

2. The method of claim 1 wherein the polyphenol contains at least three phenol moieties and has a molecular weight of between 280 and 6,000.

3. The method of claim 2 wherein the tree is a Western Larch tree.

4. The method of claim 1 wherein the polyphenol is a flavonoid.

5. The method of claim 4 wherein the flavonoid is selected from the group consisting of tannins, taxifolins, catecholines, anthocyanins and catechins.

6. The method of claim 1 wherein the composition is administered in a dosage of between 10 and 300 mg/kg body weight.

7. The method of claim 1 further comprising adding a carrier to the composition.

8. The method of claim 7 wherein the carrier is food.

9. The method of claim 8 wherein the composition is added to food in a concentration effective to increase the relative ratio of Bifidobacteria to Clostridia.

10. The method of claim 8 wherein the composition is added to food in a concentration of between 0.1 and 5% by weight of the food.

11. The method of claim 8 wherein the composition is added to food in a concentration of between 0.1 and 2% by weight of the food.

12. The method of claim 1 wherein the animal is selected from the group consisting of poultry, swine, horses, calves, dogs and cats.

13. The method of claim 5 wherein the polyphenol is taxifolin.

14. The method of claim 13 wherein the plant extract containing arabinogalactan and a polyphenol is isolated from a tree of the genus Larix by extraction of chipped or pulverized wood of the tree with water.

15. The method of claim 14 wherein the water has a pH between about 7 and 12.