Topical composition for treatment of blepharitis
First Claim
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1. An ophthalmic pharmaceutical composition suitable for direct instillation into the eye and comprising:
- a nitroimidazole compound present in an amount in the range of 0.1-2% by weight of the composition and effective to treat blepharitis and blepharoconjunctivitis in an animal or human patient; and
an ophthalmic carrier for said nitroimidazole compound, said carrier being suitable for topical application to ocular tissues.
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Abstract
A pharmaceutical composition for treating blepharitis or blepharoconjunctivitis is disclosed for topical administration comprising a nitroimidazole, as metronidazole, in a suitable ophthalmic carrier to be applied directly to affected ocular tissues. The carrier may be an artificial tear solution, an ointment, a water soluble gel, a nonaqueous carrier or an eyelash shampoo.
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Citations
27 Claims
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1. An ophthalmic pharmaceutical composition suitable for direct instillation into the eye and comprising:
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a nitroimidazole compound present in an amount in the range of 0.1-2% by weight of the composition and effective to treat blepharitis and blepharoconjunctivitis in an animal or human patient; and an ophthalmic carrier for said nitroimidazole compound, said carrier being suitable for topical application to ocular tissues. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A pharmaceutical composition, comprising:
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an amount of nitroimidazole compound effective to treat blepharitis and blepharoconjunctivitis in an animal or human patient; and a carrier for said nitroimidazole compound, said carrier suitable for topical application to ocular tissues, wherein said carrier includes an artificial tear composition which is either hypertonic, isotonic, or hypotonic. - View Dependent Claims (17, 18, 19, 20, 21, 22)
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23. A pharmaceutical composition, comprising:
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an amount of nitroimidazole compound effective to treat blepharitis and blepharoconjunctivitis in an animal or human patient; and a hypotonic carrier for said nitroimidazole compound, said carrier suitable for topical application to ocular tissues.
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24. A pharmaceutical composition, comprising:
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an amount of nitroimidazole compound effective to treat blepharitis and blepharoconjunctivitis in an animal or human patient; and a hypertonic carrier for said nitroimidazole compound, said carrier suitable for topical application to ocular tissues.
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25. A pharmaceutical composition, comprising:
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an amount of nitroimidazole compound effective to treat blepharitis and blepharoconjunctivitis in an animal or human patient; and an isotonic carrier for said nitroimidazole compound, said carrier suitable for topical application to ocular tissues.
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26. A pharmaceutical composition, comprising:
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an amount of a nitroimidazole compound effective to treat blepharitis and blepharoconjunctivitis in an animal or human patient; and a carrier for said nitroimidazole compound, said carrier suitable for topical application to ocular tissues, wherein said carrier is a shampoo suitable for cleansing eyelashes.
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27. A pharmaceutical composition, comprising:
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an amount of a nitroimidazole compound effective to treat rosacea of the scalp in an animal or human patient; and a carrier for said nitroimidazole compound, said carrier suitable for topical application to scalp tissues, wherein said carrier is a shampoo suitable for cleansing the scalp and hair or fur.
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Specification