Injection-molded dosage form

• US 5,614,578 A
• Filed: 10/28/1994
• Issued: 03/25/1997
• Est. Priority Date: 10/28/1994
• Status: Expired due to Term

• Current Assignee: Encinal Pharmaceutical Investments, LLC
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Ferrari, Vincent J., Dong, Liang C., Wong, Patrick S. L., Pollock, Crystal
• Primary Examiner(s): Szekely, Peter A.
• Application Number:
  US08/330,892
• Time in Patent Office: 879 Days
• Field of Search: 524/43, 524/377, 525/408
• US Class Current: 524/377
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/2095 Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: B01D 71/48 Polyesters
• CPC Class Codes: C08L 1/284 with hydroxylated hydrocarbon radicals
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 2666/18 Polyesters or polycarbonates according to C08L67/00 - C08L69/00; Derivatives thereof
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 71/00 Compositions of polyethers obtained by reactions forming an ether link in the main chain of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

A dosage form is disclosed comprising an injection-molded housing member free of organic solvents.

Claims

1. A composition comprising 10% to 97 wt % polycaprolactone, 10% to 97 wt % poly(alkylene oxide) and 1% to 97 wt % of poly(ethylene glycol) with the composition equal to 100 wt %.

2. A composition comprising 1% to 90 wt % polycaprolactone, 1% to 90 wt % poly(alkylene oxide) 1% to 90 wt % poly(hydroxypropylcellulose) and 1% to 90 wt % poly(ethylene glycol) which composition is used for injection-molding a membrane, and equals 100 wt %.

3. A composition comprising 20% to 90 wt % polycaprolactone and 10% to 80 wt % poly(hydroxypropylcellulose), which composition is useful for injection-molding a membrane and equals 100 wt %.