Polyacrylate and Polymethacrylate ester based hydrogel adhesives
First Claim
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1. A hydrogel adhesive comprising a copolymer formed by copolymerizing and cross-linking a first water soluble monomer having the structure (I) ##STR7## where, R1 is selected from the group consisting of H and CH3 ;
- R2 is selected from the group consisting of a straight or branched chain alkyl radical of 2-12 carbon atoms, a straight or branched chain aliphatic ester of 5-12 carbon and oxygen atoms, and a straight or branched chain ether radical of 3-12 carbon and oxygen atoms;
X is an ionic group selected from the group consisting of SO3-, COO- and ##STR8## where R3, R4, and R5 are independently selected from the group consisting of H and alkyl groups of 1-4 carbon atoms;
with a second water soluble monomer having the structure (II)
space="preserve" listing-type="equation">CH.sub.2 ═
CH--Y (II)where Y is selected from the group consisting of ##STR9## where R6, R7 are independently selected from the group consisting of H and alkyl groups of 1-3 carbon atoms;
in the presence of water, a multifunctional cross-linking agent, and a humectant;
wherein said first water soluble monomer is selected from the group consisting of potassium-3-sulfopropyl acrylate, potassium-3-sulfopropyl methacrylate, 2-carboxyethylacrylate, 2-sulfoethylmethacrylate, and methacryloxyethyl trimethylammonium chloride; and
wherein said second water soluble monomer is selected from the group consisting of acrylic acid, acrylamide, alkylated acrylamides, vinyl pyrrolidone, vinyl sulfonic acid, and vinyl phosphonic acid.
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Abstract
A hydrogel adhesive made of a polymer formed by polymerizing a water soluble long chain (meth)acrylate ester monomer (structure I); a hydrogel adhesive made of a copolymer formed by copolymerizing a first water soluble long chain (meth)acrylate ester monomer (structure I) with a second water soluble monomer (structure II); biomedical devices having such hydrogel adhesives; a method of preparing hydrogel adhesives; and a method of adhering biomedical devices to skin.
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8 Claims
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1. A hydrogel adhesive comprising a copolymer formed by copolymerizing and cross-linking a first water soluble monomer having the structure (I) ##STR7## where, R1 is selected from the group consisting of H and CH3 ;
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R2 is selected from the group consisting of a straight or branched chain alkyl radical of 2-12 carbon atoms, a straight or branched chain aliphatic ester of 5-12 carbon and oxygen atoms, and a straight or branched chain ether radical of 3-12 carbon and oxygen atoms; X is an ionic group selected from the group consisting of SO3-, COO- and ##STR8## where R3, R4, and R5 are independently selected from the group consisting of H and alkyl groups of 1-4 carbon atoms; with a second water soluble monomer having the structure (II)
space="preserve" listing-type="equation">CH.sub.2 ═
CH--Y (II)where Y is selected from the group consisting of ##STR9## where R6, R7 are independently selected from the group consisting of H and alkyl groups of 1-3 carbon atoms; in the presence of water, a multifunctional cross-linking agent, and a humectant; wherein said first water soluble monomer is selected from the group consisting of potassium-3-sulfopropyl acrylate, potassium-3-sulfopropyl methacrylate, 2-carboxyethylacrylate, 2-sulfoethylmethacrylate, and methacryloxyethyl trimethylammonium chloride; and wherein said second water soluble monomer is selected from the group consisting of acrylic acid, acrylamide, alkylated acrylamides, vinyl pyrrolidone, vinyl sulfonic acid, and vinyl phosphonic acid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification