Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof
First Claim
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1. A compound of the formula ##STR18## or a pharmaceutically acceptable salt thereof.
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Abstract
The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.
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4 Claims
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1. A compound of the formula ##STR18## or a pharmaceutically acceptable salt thereof.
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2. A compound of the formula ##STR19## or a pharmaceutically acceptable salt thereof.
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3. A compound of the formula ##STR20## or a pharmaceutically acceptable salt thereof.
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4. A compound of the formula ##STR21## or a pharmaceutically acceptable salt thereof.
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Current AssigneeSugen Incorporated (Pharmacia Corp.)
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Original AssigneeSugen Incorporated (Pharmacia Corp.)
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InventorsMcMahon, Gerald, Tang, Peng C.
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Primary Examiner(s)Richter, Johann
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Assistant Examiner(s)LUTZ, LAURA REBEKAH
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Application NumberUS08/599,453Time in Patent Office428 DaysField of Search549/389US Class Current549/389CPC Class CodesC07D 311/92 Naphthopyrans; Hydrogenated...
