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Automated optical alignment system and method using Raman scattering of capillary tube contents

  • US 5,614,726 A
  • Filed: 03/23/1995
  • Issued: 03/25/1997
  • Est. Priority Date: 03/23/1995
  • Status: Expired due to Term
First Claim
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1. An optical alignment assembly for fluorescence detection, utilizing a capillary tube, comprisingan axially symmetrical concave reflector having a wall bounded by a rim, a bowl opposite the rim incorporating a vertex, a focal region, a set of tube guides defined by the wall, the tube guides allowing passage of the capillary tube through the reflector, and a beam guide means defined by the wall for directing an excitation beam such that a path of the beam intersects with the capillary tube within the reflector, a region of intersection emitting Raman scatter signals,means disposed for collecting and detecting the Raman scatter signals, andmeans connected to the detecting means for adjusting position of the beam relative to the capillary tube to maximize the detected Raman scatter signals.

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