Method of predicting body cell mass using bioimpedance analysis

• US 5,615,689 A
• Filed: 12/12/1994
• Issued: 04/01/1997
• Est. Priority Date: 12/12/1994
• Status: Expired due to Fees

• Current Assignee: St Luke's-Roosevelt Hospital
• Original Assignee: St Luke's-Roosevelt Hospital
• Inventors: Kotler, Donald P.
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US08/353,933
• Time in Patent Office: 841 Days
• Field of Search: 128/734, 128/774, 128/630, 128/632, 128/693, 128/741
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/4872 Body fat

Abstract

The inability to precisely estimate body composition using simple, inexpensive and easily applied techniques is an impediment to clinical investigations in nutrition. In this study, predictive equations for body cell mass (BCM), fat free mass (FFM), and total body water (TBW), were derived, using single frequency bioimpedance analysis (BIA), in 332 subjects, including white, black and hispanic men and women, both normal healthy controls and patients infected with the human immunodeficiency virus (HIV). Preliminary studies demonstrated more accurate predictions of BCM when using parallel transformed values of reactance than the values reported by the bioimpedance analyzer. Modeling equations derived after logarithmic transformation of height, reactance and impedance were more accurate predictors than equations using height² /resistance, and the use of gender-specific equations further impoved accuracy. The addition of weight to the modeling equation also improved accuracy but was less important than the impedance measurements. The resulting equations were internally validated, and race, disease (HIV infection) and malnutrition were shown not to affect the predictions. The equation for FFM also was validated externally against results derived from hydrodensitometry measurements in a group of 440 healthy individuals, with a standard error of the estimate of under 5%. These results indicate that body composition can be estimated accurately using simple, inexpensive, and easily applied techniques, and that the estimates are sufficiently precise for use in clinical investigation and clinical practice.

Claims

1. A method for predicting body cell mass, fat free mass, and total body water of a person, said method comprising the steps of:

measuring height and weight of said person;

providing at least one signal representative of the measured height and weight;

measuring impedance of said person, said impedance comprising a resistance value and a reactance value;

correcting said measured impedance to indicate a value for said reactance in parallel to said resistance;

providing at least one signal representative of the corrected impedance;

calibrating at least one of the signals according to the sex of said person; and

predicting body cell mass, fat free mass, and total body water of said person using the signals.

2. The method of claim 1, wherein the impedance measuring step comprises the step of using a bioimpedance analyzer.

3. The method of claim 2, wherein the bioimpedance analyzer is a single frequency bioimpedance analyzer.

4. The method of claim 1, wherein the predicting step further comprises determining body cell mass (BCM), fat free mass (FFM), and total body water (TBW) of the person, according to:

FFM=0.54[Ht¹.76 /(11.28)Z_p⁰.31 ]+0.37(Wt)+1.55 (for males);

FFM=0.89[Ht¹.91 /(51.87)Z_p⁰.24 ]+0.10(wt)-1.07 (for females);

BCM=0.76[(59.06)Ht¹.60 /Z_p⁰.50 ]+18.52(Wt)-386.66 (for males);

BCM=0.96[(1.30)Ht².07 /Xc_p⁰.36 ]+5.79(Wt)-230.51 (for females);

TBW=0.58[Ht¹.62 /(1.35)Z_p⁰.70 ]+0.32(Wt)-3.66 (for males); and

TBW=0.76[Ht¹.99 /(18.91)Z_p⁰.58 ]+0.14(Wt)-0.86 (for females);

where;

Ht=height (cm)

Xc_p =parallel transformed reactance (ohms)

Z_p =parallel impedance (ohms)

Wt=weight (kg).